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Effect of propranolol on enzymatic and histochemical estimates of infarct size in experimental myocardial infarction

Einfluß von Propranolol auf die Größe eines experimentellen Herzinfarktes bei enzymatischer und histochemischer Bestimmung

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Summary

Acute myocardial infarction was produced in anesthetized dogs by ligation of the left anterior descendens coronary artery. Propranolol (2 mg/kg i.v.) administered 4 hours post ligation was examined for its ability to reduce infarct size estimated by histochemical and enzymatic methods. There was a significant correlation between these two methods in their estimation of infarct size. Treatment with propranolol significantly decreased infarct size estimated with both methods. It is concluded that some portion of the myocardium can be protected against infarction by pharmacologic intervention as late as 4 hours after the onset of coronary artery occlusion.

Zusammenfassung

Bei narkotisierten Hunden wurde durch Ligatur des absteigenden Astes der linken Koronararterie ein akuter Myokardinfarkt erzeugt. Es wurde geprüft, inwieweit Propranolol (2 mg/kg i.v., 4 Stunden nach Ligatur) die nach histochemischen und enzymatischen Methoden bestimmte Infarktgröße reduziert. Zwischen den Ergebnissen beider Methoden fand sich eine signifikante Korrelation. Aufgrund beider Methoden ergab sich eine eindeutige Abnahme der Infarktgröße als Folge der Propranololbehandlung. Es wird geschlossen, daß-noch 4 Stunden nach Arterienokklusion — ein gewisser Anteil des Myokards durch die pharmakologische Intervention gegen Infarzierung geschützt werden kann.

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Author notes

  1. G. J. Jesmok

    Present address: Department of Pharmacology, Medical College of Wisconsin, Box 26509, 53226, Milwaukee, Wisconsin, (USA)

Authors and Affiliations

  1. Department of Pharmacology, Medical College of Wisconsin, Box 26509, 53226, Milwaukee, Wisconsin, (USA)

    D. C. Warltier (a fellow of the National Science Foundation), G. J. Gross & H. F. Hardman

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  1. G. J. Jesmok
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  2. D. C. Warltier
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  3. G. J. Gross
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  4. H. F. Hardman
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Additional information

With 2 figures and 3 tables

This study was supported by USPHS Grant HL 08311.

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Jesmok, G.J., Warltier, D.C., Gross, G.J. et al. Effect of propranolol on enzymatic and histochemical estimates of infarct size in experimental myocardial infarction. Basic Res Cardiol 73, 559–570 (1978). https://doi.org/10.1007/BF01906794

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  • DOI: https://doi.org/10.1007/BF01906794

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