Summary
The effect of swimming instantly following an injection of isoproterenol was studied in rats in whom the administration of the drug caused changes in the cardiac muscle. The animals were compared with those of a group kept only under normal cage activity after the administration.
Oxygen inhalation in the exercised group of rats was higher than in the sedentary group and after 4 minutes of measuring, continually remained at a higher level.
It was determined that swimming prevented the early death of the rats. This was more pronounced in the animals of higher body weight. The extent of myocardial damage in the exercised group was markedly smaller.
The intensity of enzyme reaction, SDH, LDH and G6PDH, in the area of undamaged tissue was the same in both the exercised and sedentary groups, in areas of damage it was minimal. The intensity of α GP was lowered in the exercised group, but in the sedentary group it was lowered throughout the entire section.
Electronoptic examination of the tissue, which under the light microscope appeared normal, revealed no substantial differences between the exercised and sedentary groups.
We presume that the better condition of the rats was in part due to the peripheral breakdown of the catecholamine owing to be increased blood flow created by muscular activity.
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References
Bòzner, A.: Pathological changes of the cardiac muscle in electron microscopic picture (in Slovak). Dèrer's Collection, vol. 61, Osveta (Martin 1980).
Burch, G. E., T. Giles: Aspects of the influence of psychic stress on angina pectoris. Amer. J. Cardiol.31, 108–110 (1973).
Coleman, H. N., E. H. Sonnenblick, E. Braunwald: Mechanism of norepinephrine-induced stimulation of myocardial oxygen consuption. Amer. J. Physiol.221, 778–783 (1971).
Dunhill, M. S.: Quantitative methods in the study of pulmonary pathology. Thorax 320–328 (1962).
Eckstein, R. W.: Effect of exercise and coronary artery narrowing on coronary collateral circulation. Circulat. Res. 230–235 (1975).
Fleckenstein, A., J. Janke, H. J. Döring, O. Leder: Key role of Ca in the production of noncoronarogenic myocardial necroses. Pathophysiol. Morphol. of Myocard Cell Alteration, VI, University Park Press (Baltimore 1975).
Mráz, M., J. Šedivý, N. Gaier, L. Protivová, E. Faltová, J. Pilný: The influence of isoproterenol on the myocardial metabolism (in Czech). Reported on Pharmacological Days (Prague 1973).
Haskell, V. L.: Cardiovascular complications during exercise training of cardiac patients. Circulation57, 920–924 (1978).
Charvát, J.: Life, adaptation and stress (in Czech). Avicenum (Prague 1973).
Jennings, R. B., H. K. Havkins, J. E. Lowe, M. L. Hill, S. Klotman, K. A. Reimer: Relation between high energy phosphate and lethal injury in myocardial ischemia in the dog. Amer. J. Pathol.92, 187–207 (1978).
Jeschke, J., M. Kučera, J. Sova, J. Suchan: Relationship of findings on ECG, ventilation and respiration functions in bicycle ergometry of patients with infarction of the myocardium (in Czech). Lekař a těl. výchova (Prague 1975).
Kahn, D. S., G. Rona, C. I. Chappel: Isoproterenol-induced cardiac necrosis. Ann. N.Y. Acad. Sci.156, 285–293 (1969).
Lojda, Z., F. Papoušek: Priciples of histochemical determination of enzymes (in Czech). Ustav pro další vzdělávání SZP (Brno 1970).
Lojda, Z., R. Gossrau, T. H. Schiebler: Enzymhistochemische Methoden. Springer-Verlag (Berlin-Heidelberg-New York 1976).
Mitová, M., J. Vomela, V. Plíšek, M. Mráz, J. Pilný, V. Tomášek, J. Pinka, J. Novák: The course of an experimentally induced cardiac damage (in Czech). Rozhledy v chirurgii, No. 2 (1979).
Rooke, T., H. V. Sparks: Arterial CO2, myocardial O2 consumption and coronary blood flow in the dog. Circulat. Res.47, 217–225 (1980).
Selye, H.: Life and stress (in Slovak). Obzor (Bratislava 1966).
Takenaka, F., M. Higuchi: High-energy phosphate contents of subepicardium and subendocardium in the rat treated with isoproterenol and some other drugs. J. Mol. Cell. Cardiol. 123–135 (1974).
Wexler, B. C.: Acute enzyme and metabolic changes in arteriosclerotic vs nonarteriosclerotic rats following isoproterenol-induced myocardial infarction. Angiology 251–261 (1971).
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Mitova, M., Bednařík, B., Černý, E. et al. Influence of physical exertion on early isoproterenol-induced heart injury. Basic Res Cardiol 78, 131–139 (1983). https://doi.org/10.1007/BF01906667
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DOI: https://doi.org/10.1007/BF01906667