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Collateral vessel formation: isolation of a transferable factor promoting a vascular response

Nebengefäßbildung: Isolierung eines übertragbaren Faktors, durch den die Gefäßreaktion gesteigert wird

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Summary

Collateral vessel formation to the kidney was induced by renal artery stenosis or embolization in six dogs. Extracts from control and collateral-forming kidneys were assessed for their ability to promote a vascular response in the hamster cheekpouch. The highly significant response evoked by particulate and soluble fractions of cytoplasm from collateral-forming kidneys suggests a humoral element in collateral vessel formation.

Zusammenfassung

Die Nebengefäßbildung der Niere bei der renalen Arterienstenose oder bei Embolie wurde an 6 Hunden untersucht. Auszüge zur kontrollierten und gleichzeitigen Nierenbildung wurden wegen ihrer Fähigkeit, eine vaskuläre Reaktion in dem Backenbeutel des Hamsters anzuregen, angelegt. Die signifikant hohe Antwort sagte aus, daß bei teilweisem und löslichem Bruch des Zytoplasmas von den gleichseitig ausgebildeten Nieren ein humorales Element bei der Nierenbildung naheliegt.

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Author notes

  1. Herbert L. Abrams

    Present address: The Department of Radiology, Harvard Medical School, 25 Shattuck Street, 02115, Boston, Massachusetts, USA

Authors and Affiliations

  1. The Department of Radiology, Harvard Medical School, 25 Shattuck Street, 02115, Boston, Massachusetts, USA

    John T. Cuttino Jr., Royal J. Bartrum Jr. & Norman K. Hollenberg

  2. Peter Bent Brigham Hospital, 25 Shattuck Street, 02115, Boston, Massachusetts, USA

    John T. Cuttino Jr., Royal J. Bartrum Jr., Norman K. Hollenberg & Herbert L. Abrams

Authors
  1. John T. Cuttino Jr.
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  2. Royal J. Bartrum Jr.
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  3. Norman K. Hollenberg
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  4. Herbert L. Abrams
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With 2 figures

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Cuttino, J.T., Bartrum, R.J., Hollenberg, N.K. et al. Collateral vessel formation: isolation of a transferable factor promoting a vascular response. Basic Res Cardiol 70, 568–573 (1975). https://doi.org/10.1007/BF01906387

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  • DOI: https://doi.org/10.1007/BF01906387

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