Summary
Experiments were carried out using the blood perfusedLangendorff dog heart preparation to determine if myocardial tissue can convert angiotensin I to angiotensin II. The administration of angiotensin I directly into the main coronary artery of the isolated heart was accompanied by an immediate increase in coronary resistance. The increase in resistance caused by the injection of angiotensin I was prevented by the simultaneous administration of antibody to angiotensin II or by converting enzyme inhibitor. These experiments clearly demonstrate that the heart can convert angiotensin I to angiotensin II and suggest a possible role for these peptides in controlling coronary blood flow.
Zusammenfassung
Am modifiziertenLangendorff-Präparat des Hundes wurde untersucht, ob das Herz in der Lage ist, Angiotensin I in Angiotensin II umzuwandeln. Die Injektion von Angiotensin I in die Koronararterie des isolierten Herzens hat einen sofortigen Anstieg des koronaren Gefäßwiderstandes zufolge. Die durch die intrakoronare Angiotensin I-Injektion verursachte Widerstandserhöhung kann sowohl durch die gleichzeitige Gabe von Antikörpern gegen Angiotensin II als auch durch die Verabfolgung von „Converting-enzyme”-Inhibition verhindert werden. Die Versuche beweisen, daß das Herz Angiotensin I in Angiotensin II umwandeln kann, und lassen vermuten, daß diese Peptide für die Steuerung der koronaren Durchblutung von Bedeutung sein könnten.
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With 3 figures and 1 table
Supported by Nebraska Heart Grant-in-Aid Award
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Gerlings, E.D., Gilmore, J.P. Evidence for myocardial conversion of angiotensin I. Basic Res Cardiol 69, 222–227 (1974). https://doi.org/10.1007/BF01906203
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DOI: https://doi.org/10.1007/BF01906203