Basic Research in Cardiology

, Volume 68, Issue 3, pp 318–334 | Cite as

Cardiac histological and serum-biochemical changes produced by various adrenergic stimulant drugs in the rat

  • E. Marmo
  • A. P. Caputi
  • R. K. Saini


  1. 1.

    The rats given isoprenaline (1–10–100 mg/kg/die/4 days i.m.) showed myocardial infarctions on histological examination as well as increase in the levels of S-GOT, S-GPT and S-LDH.

  2. 2.

    The rats treated with various adrenergic β-stimulant drugs (terbutaline, salbutamol, soterenol, isoxsuprine, chlorprenaline, metaproterenol, ISOTIOD and quinterenol; 1–10–100 mg/kg/die/4 days i.m.) neither exhibited any significant cardiac histological changes (except infiltrations by histiocytes lymphocytes and monocytes with quinterenol and Th 1165a at 100 mg/kg/die/4 days i.m.) nor any changes in the levels of S-GOT and S-GPT.

  3. 3.

    At a dose of 100 mg/kg/die/4 days i.m. of the various β-stimulant drugs, a significant increase in the levels of S-LDH was observed in the rats.



Public Health Myocardial Infarction Histological Examination Salbutamol Histological Change 
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  1. 1.

    Un trattamento con isoprenalina (1–10–100 mg/kg/die/4 gg. i.m.) determina nel ratto lesioni cardiache infartosimili e aumento della S-GOT, della S-GPT e della S-LDH.

  2. 2.

    Un trattamento (1–10–100 mg/kg/die/4 gg i.m.) con varie sostance β-adrenergiche stimolanti (terbutalina, salbutamolo, soterenolo, Th 1165a, isoxsuprina, chlorprenalina, metaproterenolo, ISOTIOD, quinterenolo) non determina nel ratto significative modificazioni della istologia del miocardio (ad eccezione di circoscritti infiltrati istio-linfomonocitari nel miocardio di ratti trattati con 100 mg/kg/die/4 gg. i.m. di Th 1165a e di quinterenolo) e della S-GOT e della S-GPT.

  3. 3.

    Un trattamento (100 mg/kg/die/4 gg. i.m.) con varie sostanze β-adrenergiche stimolanti determina nel ratto un significativo aumento della S-LDH.



  1. 1.

    Die Gabe von Isoprenalin (1–10–100 mg/kg/die für 4 Tage, im.) verusachi bei der Ratte histologsich infarktähnliche Myokardveränderungen und Erhöhung der S-GOT, der S-GPT und der S-LDH.

  2. 2.

    Eine Behandlung mit verschiedenen β-adrenergisch stimulierenden Substanzen (Terbutalin, Salbutamol, Soterenol, Th 1165a, Isoxsuprin, Chlorprenalin, Metaproterenol, ISOTIOD, Quinterenol; 1–10–100 mg/kg/die für 4 Tage i.m.) verursacht an der Ratte keine bedeutenden Veränderungen der Histologie des Myokards (mit Ausnahme von begrenzten histio-lymphomonozytären Infiltrationen im Myokard von Ratten, die mit 100 mg/kg/die für 4 Tage i.m. Quinterenol und Th 1165 a behandelt wurden), der S-GOT und der S-GPT.

  3. 3.

    Eine Behandlung (100 mg/kg/die für 4 Tage, i.m.) mit verschiedenen β-adrenergisch stimulierenden Substanzen, verursacht an der Ratte eine bedeutende Erhöhung der S-LDH.



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Copyright information

© Dr. Dietrich Steinkopff Verlag 1973

Authors and Affiliations

  • E. Marmo
    • 1
  • A. P. Caputi
    • 1
  • R. K. Saini
    • 1
  1. 1.Department of Pharmacology and ToxicologyUniversity of Naples(Italy)

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