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Chronic hepatic injury following experimental viral hepatitis in the dog

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Zusammenfassung

20 junge, nicht immune Beagle Hunde (Neutralisationstiter < 1/4) wurden mit 300 ID50 (Gewebskultur) des Hepatitis-canis-Virus infiziert. Alle Tiere starben innerhalb von 4–6 Tagen an ausgedehnter Lebernekrose. Im Gegensatz dazu überlebten 16 partiell immune Tiere (Neutralisationstiter 1/4 bis 1/100) die akute Erkrankung. Im Verlaufe einer Überlebenszeit bis zu 8 Monaten entwickelte sich eine der menschlichen Hepatitis chronica ähnliche Lebererkrankung.

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Authors and Affiliations

  1. Department of Clinical Pharmacology, University of Berne, Switzerland

    R. Preisig, D. Gocke, T. Morris & S. E. Bradley

  2. Department of Medicine, Columbia University, New York, N.Y., USA

    R. Preisig, D. Gocke, T. Morris & S. E. Bradley

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  1. R. Preisig
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  2. D. Gocke
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  3. T. Morris
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  4. S. E. Bradley
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Preisig, R., Gocke, D., Morris, T. et al. Chronic hepatic injury following experimental viral hepatitis in the dog. Experientia 22, 701–702 (1966). https://doi.org/10.1007/BF01902457

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  • DOI: https://doi.org/10.1007/BF01902457

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