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2,6-Dichlorobenzylidene amino guanidine acetate (Wy-8678). A new hypotensive agent

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  • Pharmacologica
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Zusammenfassung

Bei unanästhesierten Ratten und Hunden wurden die antihypertensiven Eigenschaften von 2,6-Dichlorobenzyliden-Aminoguanidin-Azetat (WY 8678), welches zu einer neuen Reihe von aktiven Substanzen gehört, sowie noch einige andere klinisch wirksame Substanzen an zwei experimentellen Modellen für Hypertension geprüft und dabei eine wesentliche Blutdrucksenkung festgestellt.

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Authors and Affiliations

  1. Pharmacological Evaluation and Organic Medicinal Chemistry Sections, Wyeth Laboratories, Inc., 19087, Radnor, Pennsylvania, USA

    T. Baum, D. K. Eckfeld, N. Metz, J. L. Dinish, G. Rowles, R. van Pelt, A. T. Shropshire, S. P. Fernandez, M. I. Gluckman & W. F. Bruce

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  1. T. Baum
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  2. D. K. Eckfeld
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  3. N. Metz
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  4. J. L. Dinish
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  5. G. Rowles
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  6. R. van Pelt
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  7. A. T. Shropshire
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  8. S. P. Fernandez
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  9. M. I. Gluckman
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  10. W. F. Bruce
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Baum, T., Eckfeld, D.K., Metz, N. et al. 2,6-Dichlorobenzylidene amino guanidine acetate (Wy-8678). A new hypotensive agent. Experientia 25, 1066–1067 (1969). https://doi.org/10.1007/BF01901433

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  • DOI: https://doi.org/10.1007/BF01901433

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