Summary
The effects ofl-threo-chloramphenicol and thiophenicol on the differentiation of sea-urchin eggs are compared with those exerted byd-threo-chloramphenicol. Onlyd-threo-chloramphenicol caused vegetalization;l-threo-chloramphenicol inhibited development. These effects resemble those of nitrobenzene. Thiophenicol, differing fromd-threo-chloramphenicol by replacing the nitro group with a methylsulphonyl group, slows down development at high concentrations. The effects of chloramphenicol on oxidative phosphorylation and synthesis of proteins are discussed. It is suggested that both the steric configuration typed-threo of the side chain and the presence of a nitro group are necessary for the vegetalizing activity.
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Lallier, R. Effets d'analogues du chloramphénicol sur la différenciation de l'∄uf de l'oursinParacentrotus lividus. Experientia 22, 724–725 (1966). https://doi.org/10.1007/BF01901340
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DOI: https://doi.org/10.1007/BF01901340