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Inhibition of amphibian egg development by histones

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Uova di Anuri (Discoglossus pictus) sono state trattate con istoni. II trattamento con la frazione ricca in lisina (0,4-0,1 mg/ml) durante la segmentazione causa blocco alle prime divisioni. Con concentrazioni minori (0,05–0,025 mg/ml) lo sviluppo si arresta allo stadio di gastrula. La sensibilità al trattamento decresce notevolmente dopo la gastrulazione. La frazione ricca in arginina è risultata meno efficace.

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Molinaro, M., Cusimano-Carollo, T. Inhibition of amphibian egg development by histones. Experientia 22, 246–247 (1966). https://doi.org/10.1007/BF01900937

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