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Effect of choline salicylates and some other analogues of salicylic acid on the replication of EMC virus in vitro

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Zusammenfassung

Es wird eine 90–99,9%ige Hemmung in vitro der Replikation des EMC-Virus durch 0,5–2 m molare Lösungen folgender Salicylsäurederivate festgestellt: Cholinsalicylat, Cholinacetoxysalicylat und der Natriumsalze von 2-Merkaptobenzoesäure, Salicylsäure sowie Acetylsalicylsäure. Ferner wurde eine etwa 70%ige Hemmung des Natriumsalzes der Sulphosalicylsäure, des Cholin-p-chlorobenzoates, sowie des Cholin-o-chlorobenzoates beobachtet. Cholin-p-oxybenzoat und Cholin-p-acetoxybenzoat zeigten hingegen keine Hemmungsaktivität.

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Authors and Affiliations

  1. Department of Virology, Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Poland

    Anna D. Inglot & Marian Kochman

  2. Department of Biochemistry, Medical School of Wroclaw, Poland

    Anna D. Inglot & Marian Kochman

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  1. Anna D. Inglot
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  2. Marian Kochman
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Acknowledgements: We are indebted to Drs. Z.Machoń and T.Zawisza from the Department of Synthesis of Drugs, School of Medicine, Wroclaw, for donating of choline salicylates and other derivatives of benzoyl-choline6.

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Inglot, A.D., Kochman, M. Effect of choline salicylates and some other analogues of salicylic acid on the replication of EMC virus in vitro. Experientia 22, 322–324 (1966). https://doi.org/10.1007/BF01900478

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  • DOI: https://doi.org/10.1007/BF01900478

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