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The adrenocorticotropic action of a new synthetic pentacosapeptide

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Résumé

L'action adrénocorticotrope d'un polypeptide à 25 acides aminés, comprenant 3 modifications de structure par rapport à la séquence 1–25 de l'ACTH naturelle est étudiée et démontrée. La destruction enzymatique de ce pentacosapeptide paraît être plus lente dans le sang que dans les tissus musculaire et sous-cutané. L'augmentation de la dose injectée produit un allongement de la durée de stimulation de la cortico-surrénale.

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  1. Department of Medicine of the University of Geneva, Hôpital cantonal, Geneva, Switzerland

    M. Jenny, A. F. Muller & R. S. Mach

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  1. M. Jenny
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  2. A. F. Muller
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  3. R. S. Mach
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Jenny, M., Muller, A.F. & Mach, R.S. The adrenocorticotropic action of a new synthetic pentacosapeptide. Experientia 22, 528–530 (1966). https://doi.org/10.1007/BF01898672

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