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Influence of serotonin on the radiation sensitivity of lactate dehydrogenase

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Zusammenfassung

Die Veränderungen in der Strahlenempfindlichkeit von Milchsäuredehydrogenase durch Serotonin, gebraucht als Serotonin-Kreatinin-Sulfat, wurden spektralphotometrisch untersucht. Die Bestrahlungsdosen variierten zwischen 0–9 · 105 R. Die Serotonin-Konzentrationen variierten zwischen 0–1,23 mM. Die D37-Dosis für eine Serotonin-Konzentration von 246μM ist ca. 34mal grösser als für die Kontrollen. Der Schutzeffekt kann durch eine Komplexbildung zwischen Serotonin und den Metallionen, die im Enzym-Molekül vorhanden sind, erklärt werden.

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Authors and Affiliations

  1. Radiation Research Laboratory, College of Medicine, University of Iowa, Iowa City

    W. Lohmann, A. J. Moss Jr., W. B. Garland & D. M. Woodall

  2. School of Pharmacy, University of Arkansas, Little Rock, Arkansas, USA

    W. Lohmann, A. J. Moss Jr., W. B. Garland & D. M. Woodall

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  1. W. Lohmann
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  2. A. J. Moss Jr.
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  3. W. B. Garland
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  4. D. M. Woodall
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Lohmann, W., Moss, A.J., Garland, W.B. et al. Influence of serotonin on the radiation sensitivity of lactate dehydrogenase. Experientia 22, 514–515 (1966). https://doi.org/10.1007/BF01898660

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