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Dopa-decarboxylase and monoamine oxidase activities in a transplantable islet cell tumour of the golden hamster

  • Specialia
  • Anatomica, Histologica, Carcinologica
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Zusammenfassung

In einem transplantierbaren Inselzelltumor des Goldhamsters, der neben 5-Hydroxytryptamin, Dopa und Dopamin eine bisher unidentifizierte, vermutlich monoaminähnliche Substanz enthält, wurde eine hohe Dopadecarboxylase- und Monoaminooxydaseaktivität gefunden. Nach Dopa-decarboxylasehemmung wurde eine starke Anhäufung von Dopa im Tumorgewebe beobachtet; dieser Befund weist auf eine schnelle Monoaminsynthese und einen schnellen Monoaminumsatz im Tumorgewebe hin.

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Authors and Affiliations

  1. Department of Pharmacology, Institute of Anatomy and Histology and Department of Biochemistry, University of Lund, Sweden

    L. Cegrell, B. Falck & A. M. Rosengren

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  1. L. Cegrell
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  2. B. Falck
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  3. A. M. Rosengren
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Additional information

This work was supported by grants from the Swedish Cancer Society (67–111) and was carried out within a research organization sponsored by the Swedish Medical Research Council (Projects No. B69-14X-56-05C and B69-14X-712-04C).

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Cegrell, L., Falck, B. & Rosengren, A.M. Dopa-decarboxylase and monoamine oxidase activities in a transplantable islet cell tumour of the golden hamster. Experientia 25, 969–970 (1969). https://doi.org/10.1007/BF01898094

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  • DOI: https://doi.org/10.1007/BF01898094

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