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Enhancement of tyrosine hydroxylation within the brain by chlorpromazine

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  • Chimica, Biochimica, Biophysica
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Zusammenfassung

Im Hirnstamm (inklusive basale Ganglien) von normothermen Ratten verstärkt Chlorpromazin die Bildung von Noradrenalin, Dopamin und Catecholaminmetaboliten aus Tyrosin, welches in die Hirnventrikel eingegeben wurde. Die Gesamtradioaktivität sowie die14C-Dopa-Konzentration im Gehirn werden durch das Medikament nicht verändert. Diese Befunde sprechen fÜr eine zerebrale Aktivierung der Tyrosinhydroxylierung durch Chlorpromazin.

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Authors and Affiliations

  1. Forschungsabteilung der F. Hoffmann-La Roche and Co. AG, CH-4002, Basel, Switzerland

    G. Bartholini & A. Pletscher

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  1. G. Bartholini
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  2. A. Pletscher
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Bartholini, G., Pletscher, A. Enhancement of tyrosine hydroxylation within the brain by chlorpromazine. Experientia 25, 919–920 (1969). https://doi.org/10.1007/BF01898062

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  • DOI: https://doi.org/10.1007/BF01898062

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