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N-(t-Aminoalkynyl)-substituted pyrrolidones as oxotremorine antagonists

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  • Pharmacologica
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Zusammenfassung

Eine Anzahl von Antagonisten zu Oxotremorin wurden durch kleine Modifikationen der Struktur des Oxotremorins erhalten. Die aktivste Verbindung, N-(1-Methyl-4-pyrrolidino-2-butinyl)pyrrolidon, ist mehr als sechsmal wirksamer als Atropin und hat eine grössere Spezifizität mit Bezug auf das Zentralnervensystem.

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Authors and Affiliations

  1. Department of Organic Chemistry, Faculty of Pharmacy, Box 6804, 11386, Stockholm, Sweden

    S. Lindgren, Å. Lindquist, B. Lindeke, U. Svensson, B. Karlén, R. Dahlbom & M. R. Blair Jr

  2. Research Laboratories, Astra Pharmaceutical Products Inc., 01606, Worcester, Massachusetts, USA

    S. Lindgren, Å. Lindquist, B. Lindeke, U. Svensson, B. Karlén, R. Dahlbom & M. R. Blair Jr

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  1. S. Lindgren
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  2. Å. Lindquist
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  3. B. Lindeke
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  4. U. Svensson
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  5. B. Karlén
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  6. R. Dahlbom
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  7. M. R. Blair Jr
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Lindgren, S., Lindquist, Å., Lindeke, B. et al. N-(t-Aminoalkynyl)-substituted pyrrolidones as oxotremorine antagonists. Experientia 26, 1232–1233 (1970). https://doi.org/10.1007/BF01897984

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  • DOI: https://doi.org/10.1007/BF01897984

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