Summary
Polysaccharides glucan and laminarin produce a practically identical preventive effect in experimental staphylococcic sepsis and secure the survival of 76–83% of mice, whereas in control experiments the death rate is 90%.
Substantial differences have been revealed in the action of these preparations in sepsis caused by gram-negative microorganisms (E coli.,B. typhi abdominalis,Proteus mirabilis). Glucan in a dose of 20 mg/kg infected intraperitoneally averted the death of animals, whereas laminarin in the same dose proved ineffective.
Glucan injected intraperitoneally or intravenously in a dose of 20 mg/kg produced a pronounced antitumor effect against Ehrlich's turmor and sarcoma 180, inhibiting the tumor growth by 53–60%. No inhibitory activity of laminarin with regard to S-180 and Ehrlich's tumor was found under analoguous conditions.
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Fomina, I.P., Navashin, S.M., Preobrazhenskaya, M.E. et al. Comparative study of the biological action of the polysaccharide glucan and laminarin. Bull Exp Biol Med 61, 552–556 (1966). https://doi.org/10.1007/BF01892452
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DOI: https://doi.org/10.1007/BF01892452