Skip to main content
SpringerLink
Log in

The effect of β-mercaptoprophylamine on the cardiovascular system and the morphological composition of peripheral blood

  • Pharmacology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Summary

Beta-mercaptoprophylamine (MPA) in small concentrations causes an increase, in the amplitude of contractions of an isolated heart, and in large concentrations — a decrease with a simultaneously rising rhythm frequency; in a 1:100 dilution it causes stoppage of the heart in the diastole.

The effect of MPA on the cardiovascular system and respiration in rabbits was manifesred by a brief lessening of the blood pressure and stimulation of respiration. Cats were found to have a biphasic character of an arterial pressure change: at first a decrease and then an increase.

The depressor effect of the preparation is offset by preliminary atropinization. The pressor effect was lessened by serving the vagus nerves.

MPA does not produce a substantial influence on the morphological composition of the peripheral blood, homor globin level and, ESR but accelerates clotting, of the blood and increases the strength of capillaries.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Literature Cited

  1. S. Ya. Arbuzov, Vestn. AMN SSSR, No. 6 (1958), p. 10.

    Google Scholar 

  2. P. G. Zherebchenko, I. G. Krasnykh, E. I. Kuznets et al., Med. Radiol., No. 3 (1962), p. 67.

    Google Scholar 

  3. Z. I. Zhulanova, In book: Collection of Abstracts on Radiation Medicine [in Russian], Vol. 5, Moscow (1962), p. 139.

  4. A. I. Zhuravlev and B. N. Tarusov, Radiobiologiya, No. 2 (1962), p. 177.

    Google Scholar 

  5. I. G. Krasnykh, P. G. Zherebchenko, V. S. Murashova et al.,Ibid.,, No. 2, (1962), p. 298.

    Google Scholar 

  6. D. V. Mangina,Ibid.,, No. 2 (1963), p. 240.

    Google Scholar 

  7. F. Yu. Rachinskii, A. S. Mozzhukin, N. M. Slavachevskaya et al., Uspekhi Khimii, Vol. 28, No. 12 (1959), p. 1488.

    Google Scholar 

  8. E. F. Romantsev, Radiation and Chemical Protection [in Russian], Moscow (1963).

  9. N. L. Solomin, In book: Collection of Scientific Papers of the Sverdlovsk Scientific Research Institute for Dermatology and Venerology and the Department of Skin and Venereal Diseases [in Russian], Sverdlovsk. Med. Inst., Vol. 4, Sverdlovsk (1962), p. 186.

  10. V. G. Yakovlev, Collection of Abstracts on Radiation Medicine [in Russian], Vol. 5, Moscow (1962) p. 128.

    Google Scholar 

  11. I. A. Cohen, O. Vos, and D. W. van Bekkum, In book: Advances in Radiobiology, Edinburgh (1957), p. 13.

Download references

Author information

Authors and Affiliations

  1. Moscow

    V. A. Kozlov

Authors
  1. V. A. Kozlov
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kozlov, V.A. The effect of β-mercaptoprophylamine on the cardiovascular system and the morphological composition of peripheral blood. Bull Exp Biol Med 61, 548–551 (1966). https://doi.org/10.1007/BF01892451

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01892451

Keywords

Search

Navigation