Gastrointestinal Radiology

, Volume 14, Issue 1, pp 100–102 | Cite as

The effect of glucagon on esophageal peristalsis and clearance

  • Mehran Anvari
  • Dafydd Richards
  • John Dent
  • William E. Waterfall
  • Giles W. Stevenson
Article

Abstract

The effect of 0.5 mg intravenous glucagon on esophageal peristalsis and transit of water and barium was studied in nine healthy subjects by concurrent videofluoroscopy and manometry.

Glucagon lowered manometric peristaltic amplitude in both mid- and distal esophagus. This reached significance (p=0.0075) in the distal 3 cm of the esophagus 2 min after the injection. The efficiency of esophageal stripping was also reduced (increased proximal escape on fluoroscopy), and became significant (p=0.05) at 2 min after the injection of glucagon.

Key words

Esophageal peristalsis, glucagon Radiology 

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Copyright information

© Springer-Verlag New York Inc. 1989

Authors and Affiliations

  • Mehran Anvari
    • 1
  • Dafydd Richards
    • 2
  • John Dent
    • 3
  • William E. Waterfall
    • 1
  • Giles W. Stevenson
    • 4
  1. 1.Department of SurgeryMcMaster University Medical CentreHamiltonCanada
  2. 2.Department of RadiologyNeath HospitalWest GlamorganWales, UK
  3. 3.Department of GastroenterologyRoyal Adelaide HospitalAdelaideAustralia
  4. 4.Department of RadiologyMcMaster University Medical CentreHamiltonCanada

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