Gastrointestinal Radiology

, Volume 17, Issue 1, pp 300–304 | Cite as

Gd-DTPA as an intestinal contrast agent for MR imaging of the lower abdomen: Phase III clinical trial

  • L. Vlahos
  • A. Gouliamos
  • W. Clauss
  • A. Kalovidouris
  • A. Athanasopoulou
  • A. Petroulakis
  • A. Hadjiioannou
  • C. Papavasiliou
Article

Abstract

Thirty-one patients were investigated with magnetic resonance (MR) imaging of the lower abdomen before and after the administration of gadopentetate dimeglumine (Gd-DTPA) solution per os or per rectum or from both routes for the opacification of the intestinal tract. The parameters evaluated were: (a) contrast medium distribution, (b) degree of filling of the bowel lumen, (c) contrast between the bowel lumen and the surrounding normal or pathological structures, and (d) whether the administration of the contrast agent improved the diagnostic ability of MR compared to computed tomography (CT) or plain MR of the same region. Gd-DTPA, at a concentration of 1 mmol/L, produced a positive signal irrespective of its dilution in the bowel and good contrast between the bowel lumen and the adjacent tissues or any possible pathological lesions. From the diagnostic point of view, after the administration of contrast medium, MR is comparable to CT and much superior to plain MR. It is concluded that opacification of the bowel with Gd-DTPA solution will improve the diagnostic yield of MR imaging of the lower abdomen.

Key words

MR imaging Gd-DTPA MR contrast media Paramagnetic contrast media 

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Copyright information

© Springer-Verlag New York Inc. 1992

Authors and Affiliations

  • L. Vlahos
    • 1
    • 2
  • A. Gouliamos
    • 1
    • 2
  • W. Clauss
    • 1
    • 2
  • A. Kalovidouris
    • 1
    • 2
  • A. Athanasopoulou
    • 1
    • 2
  • A. Petroulakis
    • 1
    • 2
  • A. Hadjiioannou
    • 1
    • 2
  • C. Papavasiliou
    • 1
    • 2
  1. 1.Department of RadiologyUniversity Areteion HospitalAthensGreece
  2. 2.Schering A.G.BerlinFederal Republic of Germany

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