Abstract
A double-blind crossover study in 31 normal volunteers showed that intramuscular injection of ceruletide (0.3 Μg/kg) significantly accelerated small bowel transit of barium when compared to placebo. The only adverse effect was frequent pain at the injection site. There was a significant degradation in the quality of small bowel coating and distension in only 10% of the volunteers. Despite these problems, intramuscular administration of ceruletide may become a useful method for decreasing the prolonged time required for most small bowel examinations.
Similar content being viewed by others
References
Kim SK: Small intestine transit time in the normal small bowel study.AJR 104:522–524, 1968
Lonnerblad L: Transit time through the small intestine; a roentgenologic study on normal variability.Acta Radiol [Suppl] (Stockh) 88:7–78, 1951
Marshak RH, Lindner AE:Radiology of the Small Intestine. Philadelphia: WB Saunders Co 1970, pp 2–4
Eisenberg RL, Margulis AR: Conventional small bowel examinations.Cont Diagn Radiol 3:1–6, 1980
Friedenberg MJ, McAlister WH, Margulis AR: Roentgen study of the small bowel in adults and children with neostigmine.AJR 88:693–701, 1962
Goldstein HM, Poole GJ, Rosenquist CJ, Friedland GW, Zboralske FF: Comparison of method for acceleration of small intestinal radiographic examination.Radiology 98:519–523, 1971
Caldwell WL, Floch MH: Evaluation of the small bowel barium motor meal.Radiology 80:383–391, 1963
Weintaub S, Williams RG: A rapid method of roentgenologic examination of the small intestine. A preliminary report.AJR 61:45–54, 1949
Vallance R: An evaluation of the small bowel enema based on an analysis of 350 consecutive examinations.Clin Radiol 31:221–232, 1980
Skjennald A, Samset JH: Duodeno-jejunal intubation in the examination of the small intestine.Clin Radiol 31:221–224, 1980
Nolan DJ: Rapid duodenal and jejunal intubation.Clin Radiol 30:183–185, 1979
Miller RE: Reflux examination of the small bowel.Radiol Clin North Am 7:175–184, 1969
Parker Bradfield G, Crispin AR: The 90 minute follow through: a simple technique for examination of the small intestine.Gastroenterology 38:691–693, 1965
Margulis AR, Mandelstain P: The use of parenteral neostigmine in the roentgen study of the small bowel.Radiology 76:223–229, 1961
Kreel L: The use of oral metoclopramide in the barium meal and follow through examination.Br J Radiol 43:31–35, 1970
Ho CS, Rubin E, Renout JHP: Metoclopramide in gastrointestinal radiology.J Can Assoc Radiol 29:51–55, 1978
James WB, Hum R: Action of metoclopramide on gastric emptying and small bowel transit time.Gut 9:203–205, 1968
Howarth FH, Cockel R, Roper BW, Hawkins CF: The effect of metoclopramide upon gastric motility and its value in barium progress meals.Clin Radiol 20:294–300, 1969
James WB, Melrose AG: Metoclopramide in gastrointestinal radiology.Clin Radiol 20:57–60, 1969
Margieson GR, Sorby WA, Williams HBL: The action of metoclopramide on gastric emptying: a radiological assessment.Med J Aust 2:1272–1274, 1966
Efsing HO, Lindroth B: Small bowel examination after injection of cholecystokinin.Clin Radiol 31:225–226, 1980
Parker JG, Beneventano TC: Acceleration of small bowel contrast study by cholecystokinin.Gastroenterology 58:679–684, 1970
Hedner P, Rorsman G: Acceleration of the barium meal through the small intestine by the c-terminal octapeptide of cholecystokinin.AJR 116:245–248, 1972
Levant JA, Kun TL, Jachna J, Sturdevant L, Isenberg JI: The effects of graded doses of c-terminal octapeptide of cholecystokinin on small intestinal transit time in man.Am J Dig Dis 19:207–209, 1974
Thompson WM, Amberg JR: Use of the c-terminal octapeptide of cholecystokinin in clinical radiology II. The small bowel.Gastrointest Radiol 3:195–199, 1978
Novak D: Acceleration of small intestine contrast study by ceruletide.Gastrointest Radiol 5:61–65, 1980
Sargent EN, Halls JM, Colletti P, Wieler M: Efficacy and tolerance of ceruletide in radiology of the small intestine.Radiology 136:57–60, 1980
Orland I, Agosti A: Use of the new peptide caerulein in the study of the alimentary tract.Ann Radiol Diagn (Bologna) 43:341–346, 1970
Snedecor GW, Cochran WG:Statistical Methods, Ed 6. Ames, Iowa: Iowa State University Press, 1967
Huff BB: Prostigmin® Injectable (neostigmine methylsulfate/ Roche). In:Physicians' Desk Reference, Ed 34. Oradell, NJ: Medical Economics, 1980, pp 1477–1478
Huff BB: Reglan® Injectable (metoclopramide hydrochloride). In:Physicians' Desk Reference, Ed 34. Oradell, NJ: Medical Economics, 1980, pp 1433–1434
Huff BB: Kinveac® (Sincalide for injection). In:Physicians' Desk Reference, Ed 34. Oradell, NJ: Medical Economics, 1980, pp 2018–2019
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Thompson, W.M., Halvorsen, R.A., Shaw, M. et al. Evaluation of intramuscular ceruletide for shortening small bowel transit time. Gastrointest Radiol 7, 141–147 (1982). https://doi.org/10.1007/BF01887628
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01887628