A DNA double helix consists of two complementary strands antiparallel with each other. One of them is the sense chain, while the other is an antisense chain which does not directly involve the protein-encoding process. The reason that an antisense chain cannot encode for a protein is generally attributed to the lack of certain preconditions such as a promotor and some necessary sequence segments. Suppose it were provided with all these preconditions, could an antisense chain encode for an “antisense protein”? To answer this question, an analysis has been performed based on the existing database. Nine proteins have been found that have a 100% sequence match with the hypothetical antisense proteins derived from the knownEscherichia coli antisense chains.
Key wordsDNA genetic coding protein sequence match
Unable to display preview. Download preview PDF.
- Bairoch, A., and Boeckmann, B. (1994). The SWISS-PROT protein sequence data bank,Nucleic Acids Res. 22, 3575–3580.Google Scholar
- Devereux, J. (1994). The Wisconsin Sequence Analysis Package, Version 8.0, Genetics Computer Group, Madison, Wisconsin.Google Scholar
- Wada, K., Wada, Y., Doi, H., Ishibashi, F., Gojobori, T., and Ikemura, T. (1991). Codon usage tabulated from the GenBank genetic sequence data,Nucleic Acids Res. 19(Suppl), r1981-r1986.Google Scholar