Summary
Gc-subtypes were determined by isoelectric focusing and immunfixation on samples from 492 unrelated blood donors from Berlin. The frequency of the three genes was found to be Gc1F = 0.1270, Gc1S = 0.6006, Gc2 = 0.2724. Analysis of 78 parents with 190 children did not show deviations from the expected mode of inheritance. Investigation of the adults from paternity cases and of their children on the other hand obtained similar results. No rare alleles were observed.
Zusammenfassung
Die Gc-Subtypen wurden an Seren von 492 unausgewählten Berliner Blutspendern durch isoelektrische Fokussierung und Immunfixation bestimmt. Die Allelfrequenzen betragen: Gc1F = 0,1270, Gc1S = 0,6006, Gc2 = 0,2724. Die Untersuchungen an 78 Familien mit 190 Kindern ergab keine Abweichung vom angenommenen, autosomal kodominanten Erbgang. Die Untersuchungen von 636 Erwachsenen aus dem laufenden Paternitätsmerkmal sowie von 205 Kindern ergab annähernd gleiche Ergebnisse. Seltene Allele wurden im vorliegenden Material nicht beobachtet.
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Herrn Prof. Dr. Franz Schleyer zum 70. Geburtstag gewidmet
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Patzelt, D., Nagai, T., Schröder, H. et al. Die Gc-Subtypen: Darstellung mittels isoelektrischer Fokussierung. Z Rechtsmed 90, 45–52 (1983). https://doi.org/10.1007/BF01886066
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DOI: https://doi.org/10.1007/BF01886066