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Die Adrenalin- und Noradrenalinausscheidung während Angiotensin II-Infusionen in die Arteria carotis beim narkotisierten Hund

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Zusammenfassung

Die Wirkung von Angiotensin II (A II) auf den Katecholaminhaushalt wurde an 6 narkotisierten Hunden geprüft. Dabei wurden subpressorische (5 ng/kg/min) und stark pressorische (1000 ng/kg/min) Angiotensin-Dosen, denen jeweils Infusionen von 0,9%igen NaCl-Lösungen vorausgingen, in die Arteria carotis interna infundiert.

Während unter subpressorischen A II-Infusionen keine Steigerung der Katecholaminausscheidung beobachtet werden konnte, stieg die Adrenalin- und Noradrenalinexkretion unter der pressorischen A II-Gabe deutlich an. Die Erhöhung der Adrenalinausscheidung war dabei statistisch signifikant (p<0,05).

Die Ergebnisse werden im Zusammenhang mit den zum Teil unterschiedlichen Befunden anderer Autoren besprochen, wobei vor allem Fragen des Angriffspunktes und des Wirkungsmechanismus von A II, der A II-Dosierung und der Narkose erörtert werden.

Schließlich wird diskutiert, welche Bedeutung die Befunde im Hinblick auf die Pathogenese besonderer Hypertonieformen besitzen können.

Summary

The effect of angiotensin II (A II) on the release of catecholamines was examined on 6 anesthetized dogs. Subpressor (5 ng/kg/min) and high pressor doses (1000 ng/kg/min) of A II were infused into an internal carotid artery.

While subpressor doses of A II caused no increase of the catecholamine excretion, both epinephrine and norepinephrine excretion increased considerably under pressor doses of A II. The increase of the epinephrine excretion was statistically significant (p<0,05).

Considering the partly contradictory results of other authors, the discussion deals mainly with problems of dose, mode and site of action of A II and the influence of anesthesia.

Finally, a possible significance of our results for the pathogenesis of special types of arterial hypertension is discussed.

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Authors and Affiliations

  1. Medizinische Universitäts-Poliklinik und -Klinik Zürich, Switzerland

    C. Werning, M. Schönbeck, W. H. Ziegler, K. Baumann, E. Gysling, P. Weidmann & W. Siegenthaler

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  1. C. Werning
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  2. M. Schönbeck
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  3. W. H. Ziegler
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Diese Arbeit wurde durch die Hilfe des Schweizerischen Nationalfonds zur Förderung der wissenschaftlichen Forschung und der Stiftung für wissenschaftliche Forschung an der Universität Zürich ermöglicht.

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Werning, C., Schönbeck, M., Ziegler, W.H. et al. Die Adrenalin- und Noradrenalinausscheidung während Angiotensin II-Infusionen in die Arteria carotis beim narkotisierten Hund. Klin Wochenschr 47, 640–647 (1969). https://doi.org/10.1007/BF01884359

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