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Journal of Cancer Research and Clinical Oncology

, Volume 109, Issue 1, pp 72–77 | Cite as

Small-cell lung cancer and immunochemotherapy withPropionibacterium granulosum KP 45

  • K. Roszkowski
  • B. Nozdryn-Plotnicki
  • W. Roszkowski
  • H. L. Ko
  • J. Jeljaszewicz
  • G. Pulverer
Original Papers Clinical Oncology or Epidemiology

Summary

Seventy-nine patients with small-cell lung cancer were treated with vincristin, methotrexate, and cyclophosphamide in inductive therapy and with methotrexate, cyclophosphamide, and procarbazine in maintenance therapy. Patients were divided at random into two groups: one group received chemotherapy alone and the second group was additionally subjected to systemic immunotherapy withPropionibacterium granulosum strain KP-45. In general, differences in the frequency of therapy response and in duration of remission could not be stated between the two groups of patients, but patients responding to chemotherapy showed a significantly longer remission time and lower complication rates. This benificial effect of chemoimmunotherapy is not related to a direct antitumor activity of the immunomodifier used, but to the lowered risk of myelosuppression and infections. Immunomodulation in combination with chemo- and/or radiotherapy can be recommended for the treatment of small-cell lung cancer.

Key words

Small-cell lung cancer Systemic immunotherapy Propionibacterium granulosum Immunochemotherapy 

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Copyright information

© Springer-Verlag 1985

Authors and Affiliations

  • K. Roszkowski
    • 1
  • B. Nozdryn-Plotnicki
    • 2
  • W. Roszkowski
    • 1
  • H. L. Ko
    • 3
  • J. Jeljaszewicz
    • 4
  • G. Pulverer
    • 3
  1. 1.Institute of Lung Diseases and TuberculosisWarsawPoland
  2. 2.Central Outpatient Clinic of OncologyWarsawPoland
  3. 3.Institute of HygieneUniversity of CologneKöln 41Federal Republic of Germany
  4. 4.National Institute of HygieneWarsawPoland

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