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Selective induction of nasal cavity tumors in rats by diallylnitrosamine

  • Original Papers
  • Experimental Oncology
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Summary

Weekly intragastric administration of 20, 40, and 80 mg/kg body weight diallylnitrosamine to BD IX rats selectively induced nasal and paranasal cavity tumors with incidences of 30%, 85%, and 65% in females and of 0%, 75%, and 80% in males, respectively. All tumors were carcinomas of the olfactory region, and 95% were invasive. Only a few papillomas in the anterior region were found simultaneously with the carcinomas.

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Abbreviations

DAN:

diallylnitrosamine

NPN:

nasal and paranasal cavity

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Authors and Affiliations

  1. Eppley Institute for Research in Cancer, 42nd and Dewey Avenue, 68105, Omaha, NE, USA

    P. M. Pour

  2. Pediatric Gastroenterology, University of Nebraska Medical Center, 42nd and Dewey, 68105, Omaha, NE, USA

    C. J. Grandjean

  3. Department of Neuropharmacology, University of Kansas, Lawrence, Kansas, USA

    Sheila Knepper

Authors
  1. P. M. Pour
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  2. C. J. Grandjean
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  3. Sheila Knepper
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Pour, P.M., Grandjean, C.J. & Knepper, S. Selective induction of nasal cavity tumors in rats by diallylnitrosamine. J Cancer Res Clin Oncol 109, 5–8 (1985). https://doi.org/10.1007/BF01884247

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  • DOI: https://doi.org/10.1007/BF01884247

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