Summary
Factor analysis theoretically generates the time-activity curves of the various physiological compartments, or factors, which are superimposed in a dynamic series of scintigraphic frames. An image of the spatial distribution of each of these factors is also displayed. We tested the ability of one of these, the ventricular factor, to measure the left ventricular ejection fraction (LVEF) in first-pass radionuclide angiography (FPRA). Forty-nine patients divided into three groups were studied. In a group of 32 patients, factor analysis was compared to a conventional scintigraphic method and to contrast angiography. The coefficient of correlation was similar for both techniques (r = 0.83). To test reproducibility, another group of 10 patients received two successive injections of Au-195m, three minutes apart. The reproducibility of LVEF was r = 0.78 with factor analysis and r = 0.81 with the conventional method. In a third group of seven patients, three successive injections of Au-195m were performed in the right and in the left anterior oblique projections. The reproducibility of LVEF was r = 071 with factor analysis. However LVEF was significantly lower in LAO than in RAO, 50 ± 11% vs 58 ± 17% respectively. It is concluded that factor analysis does not offer a more reliable means of calculating LVEF than a conventional method.
Similar content being viewed by others
References
Di Paola R, Penel C, Bazin JC and Berche C: Factor analysis and scintigraphy. Proc IVth Conf Information Processing in Scintigraphy, Orsay, May 1975. Editors C. Raynaud and A. Todd-Pokropek, Orsay, 1975, pp 91–123
Schmidlin P, Clorius J, Kubesh R and Dreikorn K: Evaluation of dynamic studies by means of factor analysis. Proc Symp Medical Radionuclide Imaging, Los Angeles 1976, Editor, IAEA, Vienna, 1977, pp 397–408
Barber DC: The use of principal component analysis in the quantitative analysis of gamma-camera dynamic studies. Phys Med Biol 25: 283–292, 1980
Bazin JP, Di Paola R, Gibaud B et al.: Factor analysis of dynamic scintigraphic data as a modelling method. An application to the detection of metastases. Proc VIth Int Conf Information Processing in Medical Imaging, Paris, 1979. Editors R Di Paola and E Kahn, Inserm, Paris, 1980, pp 345–366
Jengo JA, Mena I, Blaufuss A, et al.: Evaluation of left ventricular function (ejection fraction and segmental wall motion) by single pass radioisotope angiography. Circulation 57: 326–332, 1978
Mena I, Narahara KA, De Jong R and Maublant JC: Gold195m, and ultrashortlived generator-produced radionuclide: clinical application in sequential first-pass ventriculography. J Nucl Med 24: 139–144, 1983
Maublant JC, Mena I, Narahara KA: Phase and amplitude analysis for detecting valve planes: an accurate and reproducible method for ejection fraction determination (Abstract). Clin Nucl Med 7: 47, 1982
Cavailloles F, Bazin JP, Di Paola R: Factor analysis in gated cardiac studies. J Nucl Med 25: 1067–1079, 1984
Maublant JC, Mena I: Validation of factorial analysis in a simulation study and in sequential cardiac first-pass acquisitions. (Abstract). J Nucl Med 25: 30, 1984
Anderson TW: An introduction to multivariate statistical analysis. John Wiley, New York, 1966
Oppenheim BE, Appledorn CR: Functional renal imaging through factor analysis. J Nucl Med 22: 417–423, 1981
Houston AS, Elliott AT, Stone DL: Factorial phase imaging: a new concept in the analysis of first-pass cardiac studies. Phys Med Biol 27: 1269–1277, 1982
Herry JY, Bazin JP, Bourguert P: Factor analysis of dynamic scintigraphic structures. Applications to kinetics of hepatobiliary tracers. Proc 3rd World Congress of Nuclear Medicine and Biology, Paris, 1982. Editor C. Raynaud, Pergamon Press, Paris, 3:2361–2364, 1982
Aurengo A, Bazin JP, Lumbroso J and Di Paola R: Factor analysis as an aid in the interpretation of dynamic scintigrams of transplanted Kidney. Proc 3rd World Congress of Nuclear Medicine and Biology, Paris 1982. Editor C. Raynaud, Pergamon Press, Paris, 4: 3167–3170, 1982
Maublant JC, Mena I: Evaluation of factorial analysis in cardiac studies. (Abstract). Clin Nucl Med 9S: 35, 1983
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Maublant, J.C., Mena, I. & Hanelin, L.G. Factor analysis in left ventricular first-pass radionuclide angiography: value of the ventricular factor to measure ejection fraction. Int J Cardiac Imag 1, 107–112 (1985). https://doi.org/10.1007/BF01884100
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01884100