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Unterschiedliche Reaktion von Lymphocyten auf Phythämagglutinin (PHA) bei Lebererkrankungen

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Zusammenfassung

Lymphocyten aus peripherem Blut von Patienten mit akuter infektiöser Hepatitis und aggressiv chronischer Hepatitis konnten in der Kultur nicht durch PHA stimuliert werden. Die RNS-Synthese unterschied sich nicht von der unstimulierter Lymphocyten. Die DNS-Synthese lag signifikant niedriger als die stimulierter Lymphocyten von Gesunden. Die Blutlymphocyten von Patienten mit Alkoholhepatitis und Arzneimittelikterus wiesen dagegen eine normale PHA-Reaktion auf. Diesen Befunden könnte eine klinisch-differentialdiagnostische Bedeutung für die Abgrenzung der akuten infektiösen Hepatitis vom Arzneimittelikterus und der Alkoholhepatitis zukommen. Die gleichartige Hemmung der PHA-Reaktion bei chronisch aggressiver Hepatitis und akuter infektiöser Hepatitis läßt auf eine gleichartige Veränderung der peripheren Lymphocyten bei beiden Erkrankungen schließen. Der Nachweis dieser Funktionsstörung könnte die Hypothese stützen, daß es sich bei der aggressiv chronischen Hepatitis um eine persistierende Virusinfektion handelt.

Summary

Peripheral lymphocytes from patients with acute infectious hepatitis and aggressive chronic hepatitis could not be stimulated by PHA in culture. The RNA synthesis was not increased above control levels. The DNA synthesis was significantly lower than in stimulated lymphocytes from healthy persons. Lymphocytes from patients with alcohol hepatitis and from patients with drug jaundice showed a normal response to PHA. These findings might be helpful in differentiating acute infectious hepatitis from alcohol hepatitis and drug jaundice. The suppression of the response to PHA in aggressive chronic hepatitis and acute infectious hepatitis suggests a similar functional lesion in peripheral lymphocytes in both diseases. This could support the hypothesis of a persisting viral infection in aggressive chronic hepatitis.

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Authors and Affiliations

  1. Medizinische Universitätsklinik Marburg a. d. Lahn, Germany

    R. Rössler, K. Havemann & W. Dölle

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  1. R. Rössler
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  2. K. Havemann
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  3. W. Dölle
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Die Untersuchungen wurden mit Unterstützung der Deutschen Forschungsgemeinschaft durchgeführt.

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Rössler, R., Havemann, K. & Dölle, W. Unterschiedliche Reaktion von Lymphocyten auf Phythämagglutinin (PHA) bei Lebererkrankungen. Klin Wochenschr 47, 803–806 (1969). https://doi.org/10.1007/BF01882306

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