Cardiovascular Drugs and Therapy

, Volume 3, Issue 1, pp 7–9 | Cite as

The captopril-digoxin multicenter resarch group study on the comparative steps of captopril and digoxin in patients with mildmoderate heart failure: Implications for therapy

  • Bertram Pitt
  • Sidney Goldstein
Focused Section on Digoxin


It is argued that the basis of therapy in a patient with mild-to-moderate congestive heart failure should be a combination of a diuretic and a converting enzyme inhibitor, with the further addition of digoxin if necessary.

Key Words

captopril digoxin congestive heart failure 


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  1. 1.
    Cohn JN, Archibald DG, Ziesche S et al. Effect of vasodilator therapy on mortality in chronic congestive heart failure.N Engl J Med 1986:314:1547–1552.PubMedGoogle Scholar
  2. 2.
    The CONSENSUS Trial Study Group. Effects of enalapril on mortality in severe congestive heart failure.N Engl J Med 1987;316:1429–1435.Google Scholar
  3. 3.
    Captopril Multicenter Study Group. A placebo trial of captopril in refractory congestive heart failure.J Am Coll Cardiol 1983;2:755–763.Google Scholar
  4. 4.
    Hlatky MA, Fleg JL, Hinton PC, et al. Physician practice in the management of congestive heart failure.J Am Coll Cardiol 1986;8:966–970.PubMedGoogle Scholar
  5. 5.
    The Captopril-Digoxin Multicenter Research Group. Comparative effects of therapy with captopril and digoxin in patients with mild to moderate heart failure.JAMA 1988;259:539–544.Google Scholar
  6. 6.
    Franciosa JA, Park M, Levine TB. Lack of correlation between exercise capacity and indexes of left ventricular performance in heart failure.Am J Cardiol 1981;47:33–39.PubMedGoogle Scholar
  7. 7.
    Ikram H, Chan W, Espiner EA, Nicholls MG, et al. Hemodynamic and hormone response to acute and chronic furosemide therapy in congestive heart failure.Clin Sci 1980;59:443–449.PubMedGoogle Scholar
  8. 8.
    Bayliss J, Norell M, Canepa-Anson R, et al. Untreated heart failure: Clinial and neuronedocrine effects of introducing diuretics.Br Heart J 1987;57:17–22.PubMedGoogle Scholar
  9. 9.
    Magrini F, Shimizu M, Roberts N, et al. Converting-enzyme inhibition and coronary blood flow.Circulation 1987; 75(Supp I):168–174.Google Scholar
  10. 10.
    Johansson BW. Hypokalemia in cardiac decompensation.Acta Pharmacol Toxicol 1984;54(Supp I):103–106.Google Scholar
  11. 11.
    Lee DC, Johnson RA, Bingham JE, et al. Heart failure in outpatients: A randomized trial of digoxin versus placebo.N Engl J Med 1986:306:699–705.Google Scholar
  12. 12.
    The German-Austrian Xamoterol Study Group. Doubleblind placebo-controlled comparison of digoxin and xamoterol in chronic heart failure.Lancet 1988;1:489–493.Google Scholar
  13. 13.
    Yusuf S, Wittes J, Bailey K, et al. Digitalis—a new controversy regarding an old drug: The pitfalls of inappropriate methods.Circulation 1986;73:14–18.PubMedGoogle Scholar
  14. 14.
    Lynch JJ, Montgomery DG, Lucchesi BR. Facilitation of lethal ventricular arrhythmias by therapuetic digoxin in conscious post-infarction dogs.Am Heart J 1986;111:883–890.PubMedGoogle Scholar

Copyright information

© Kluwer Academic Publishers 1989

Authors and Affiliations

  • Bertram Pitt
    • 1
  • Sidney Goldstein
    • 1
  1. 1.Division of CardiologyUniversity of Michigan Medical CenterAnn ArborUSA

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