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Dose response of rat liver to low level cadmium

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  1. Ashby SL, King LJ, Parke DVW (1980) Effect of acute administration of cadmium on the disposition of copper, zinc, and iron in the rat. Env Res 21: 177–185

    Google Scholar 

  2. Beutler E, Duran O, Mikus-Kelly B (1963) Improved method for the determination of blood glutathione. J Lab Clin Med 61: 882–888

    PubMed  Google Scholar 

  3. Dieter HH, Muller L, Abel J, Summer KH (1986) Determination of Cd thionein in biological materials: Comparative standard recovery by five current methods using protein nitrogen for standard calibration. Toxicol Appl Pharmacol 85: 380–388

    PubMed  Google Scholar 

  4. Dudley RE, Gammal LM, Klaassen CD (1985) Cadmium induced hepatic and renal injury in chronically exposed rats: Likely role of hepatic cadmium metallothionein in nephrotoxicity. Toxicol Appl Pharmacol 77: 414–426

    PubMed  Google Scholar 

  5. Elinder CD (1985) Cadmium: uses, occurrence and intake. In: Friberg L, Kjellstrom T, Elinder CG, Nordberg G (eds) Cadmium and Health I, Boca Raton, CRC, Fla, pp 23–63

    Google Scholar 

  6. Kawata M, Suzuki KT (1983) Relation between metal and glutathione concentration in mouse liver after cadmium, zinc or copper loading. Toxicol Lett 15: 131–137

    PubMed  Google Scholar 

  7. Maitani T, Suzuki KT (1986) Essential metal contents and metallothionein-like protein in testes of mice after cadmium administration. Toxicology 40: 1–12

    PubMed  Google Scholar 

  8. Muller L (1986) Consequences of cadmium toxicity in rat hepatocytes: Mitochondrial dysfunction and lipid peroxidation. Toxicology 40: 285–296

    PubMed  Google Scholar 

  9. Muller L, Abel J, Ohnesorge FK (1986) Absorption and distribution of cadmium (Cd), copper and zinc following subchronic low level administration to rats of different binding forms of cadmium (Cd acetate, Cd metallothionein, Cd glutathione). Toxicology 39: 187–195

    PubMed  Google Scholar 

  10. Muller L, Muller I, Stacey NH (1988) Mitochondrial effects of low level cadmium in rats: Interaction with zinc. Arch Environ Contam Toxicol, 17: in press

  11. Plishker GA (1984) Effects of cadmium and zinc on calcium uptake in human red blood cells. Am J Physiol 247: C143-C149

    PubMed  Google Scholar 

  12. Sporn A, Dinu I, Stoenescu L (1970) Influence of cadmium administration on carbohydrate and cellular energetic metabolism in the rat liver. Rev Roum Biochim 7: 299–305

    Google Scholar 

  13. Stonard MD, Webb M (1976) Influence of dietary cadmium on the distribution of the essential metals copper, zinc and iron in tissues of the rat. Chem Biol Interactions 15: 349–363

    Google Scholar 

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Correspondence to Neill H. Stacey.

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Muller, L., Craig, G. & Stacey, N.H. Dose response of rat liver to low level cadmium. Bull. Environ. Contam. Toxicol. 40, 301–308 (1988).

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  • Waste Water
  • Cadmium
  • Water Management
  • Water Pollution
  • Dose Response