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Effects of prenatal exposure to 2,4-D/2,4,5-T mixture on postnatal changes in rat brain glutamate, GABA, protein, and nucleic acid levels

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References

  1. Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248–254.

    PubMed  Google Scholar 

  2. Courtney KD, Ebron MT, Tucker AW (1977) Distribution of 2,4,5-trichlorophenoxyacetic acid in the mouse fetus. Toxicol Lett 1:103–108.

    Google Scholar 

  3. Coyle JT, Enna SJ (1976) Neurochemical aspects of the ontogenesis in the GABAnergic neurons in the rat brain. Brain Res 111:119–133.

    PubMed  Google Scholar 

  4. Crampton MA, Rogers LJ (1983) Low doses of 2,4,5-trichlorophenoxyacetic acid are behaviorally teratogenic to rats. Experientia 39:891–892.

    PubMed  Google Scholar 

  5. Dencker L (1976) The herbicide 2,4,5-T: Early placental barrier and accelerated fetal uptake with advancing gestation. Acta Pharmacol Toxicol 39:59–72.

    Google Scholar 

  6. Donzanti BA, Uretsky NJ (1983) Effects of excitatory amino acids on locomotor activity after bilateral microinjection into the rat nucleus accumbense: possible dependence on dopaminergic mechanisms. Neuropharmacology 22:971–981.

    PubMed  Google Scholar 

  7. Duffard R, De Moro GM, De Duffard AME (1982) Hatching and lipid composition of chicks brain from eggs treated with 2,4-dichlorophenoxyacetic butylester. Toxicology 24:305–311.

    PubMed  Google Scholar 

  8. Fagan K, Pollak JK (1984) The effect of the phenoxyacetic acid herbicides 2,4,5-trichlorophenoxyacetic acid and 2,4-dichlorophenoxyacetic acid as ascertained by direct experimentation, Res Rev 92:29–58.

    Google Scholar 

  9. Friedmann, JM (1984) Does Agent Orange cause birth defects? Teratology 29:193–221.

    PubMed  Google Scholar 

  10. Geel SE, Timiras PS (1967) The influence of neonatal hypothyroidism and of thyroxine on the ribonucleic acid and deoxyribonucleic acid concentrations of rat cerebral cortex. Brain Res 4:135–142.

    PubMed  Google Scholar 

  11. Graham Jr LT, Aprison MH (1966) Fluorometric determination of asparate, glutamate, and γ-aminobutyrate in nerve tissue using enzymic methods. Anal Biochem 15:487–497.

    PubMed  Google Scholar 

  12. Lin RI, Schjeide DA (1969) Micro estimation of RNA by the cupric ion catalyzed orcinol reaction. Anal Biochem 27:473–483.

    PubMed  Google Scholar 

  13. Lindquist NG, Ullberg S (1971) Distribution of the herbicides 2,4,5-T and 2,4-D in pregnant mice. Accumulation in the yolk sac. Experientia 27:1439–1441.

    PubMed  Google Scholar 

  14. Millard SA, Hart MB, Shimek JE (1973) Enzymes controlling cerebral DNA synthesis: Response to 2,4,5-trichlorophenoxyacetic and acid and hexachlorophene. Biochem Biophys Acta 308:230–233.

    PubMed  Google Scholar 

  15. Mohammad FK, St. Omer VEV (1985) Developing rat brain monoamine levels following in utero exposure to a mixture of 2,4-dichlorophenoxyacetic acids. Toxicol Lett 29:215–223.

    PubMed  Google Scholar 

  16. Mohammad FK, St. Omer VEV (1986) Behavioral and developmental effects in rats following in utero exposure to 2,4-D/2,4,5-T mixture. Neurobehav Toxicol Teratol 8:551–560.

    PubMed  Google Scholar 

  17. Munro HN, Fleck A, (1966) The determination of nucleic acids. Methods Biochem Anal 14:113–176.

    PubMed  Google Scholar 

  18. Sanderson CA, Rogers LJ (1981) 2,4,5-trichlorophenoxyacetic acid causes behavioral effects in chickens at environmentally relevant doses. Science 211:593–595.

    PubMed  Google Scholar 

  19. Sjoden PO, Soderberg U. (1978) Phenoxyacetic acids: Sublethal effects. in: Ecological Bulletins 27:149.

    Google Scholar 

  20. St. Omer VEV, Mohammad FK (1987) Ontogeny of swimming behavior and brain catecholamine turnover in rats prenatally exposed to a mixture of 2,4-dichlorophenoxyacetic acid and 2,4,5-trichlorophenoxyacetic acids. Neuropharmacology (in press).

  21. Winick M, Noble A (1965) Quantitative changes in DNA, RNA and protein during prenatal and postnatal growth in the rat. Dev Biol 12:451–466.

    PubMed  Google Scholar 

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Correspondence to V. E. V. St. Omer.

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Mohammad, F.K., Omer, V.E.V.S. Effects of prenatal exposure to 2,4-D/2,4,5-T mixture on postnatal changes in rat brain glutamate, GABA, protein, and nucleic acid levels. Bull. Environ. Contam. Toxicol. 40, 294–300 (1988). https://doi.org/10.1007/BF01881054

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Keywords

  • Waste Water
  • Glutamate
  • Nucleic Acid
  • Water Management
  • Water Pollution