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Das renale Escape-Phänomen bei Erkrankungen der Hypophyse

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Zusammenfassung

Durch Gabe von 3 mg d-Aldosteron täglich i.m. unter gleichzeitiger Natriumbelastung konnte bei einem Patienten mit Kraniopharyngeom und Panhypopituitarismus sowie bei einer Patientin mit Cushing-Symptomatik bei einem lokal malignen chromophoben Hypophysenadenom nach Hypophysencoagulation zuerst eine positive Natriumbilanz und nach einigen Tagen das typische renale Escape-Phänomen hervorgerufen werden. Die menschliche Hypophyse scheint demnach nicht entscheidend am Zustandekommen des Escape-Phänomens beteiligt zu sein. Die Theorien, die heute zur Erklärung des Escape-Phänomens herangezogen werden können, werden diskutiert.

Summary

Two patients were submitted to a constant sodium diet and 3 mg d-aldosterone/day. One of them suffered from a craniopharyngeoma and pituitary insufficiency, the other one from Cushing's syndrome due to a local malignant chromophobe adenoma of the pituitary. The patient with Cushing's syndrome was studied after coagulation of the pituitary. Both showed the typical renal escape-phenomenon after a few days. These data suggest that the pituitary does not seem to be an important factor in the renal escape-phenomenon. The theories which could account for this phenomenon are discussed.

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Authors and Affiliations

  1. Medizinische Universitäts-Poliklinik Zürich, Switzerland

    K. Baumann, E. Gysling, C. Werning & W. Siegenthaler

  2. Med. Univ.-Poliklinik, Wilhelmstr. 35–37, 5300, Bonn

    W. Siegenthaler

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  1. K. Baumann
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  2. E. Gysling
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  3. C. Werning
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  4. W. Siegenthaler
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Diese Arbeit wurde durch die Hilfe des Schweizerischen Nationalfonds zur Förderung der wissenschaftlichen Forschung und der Stiftung für wissenschaftliche Forschung an der Universität Zürich ermöglicht.

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Baumann, K., Gysling, E., Werning, C. et al. Das renale Escape-Phänomen bei Erkrankungen der Hypophyse. Klin Wochenschr 47, 866–870 (1969). https://doi.org/10.1007/BF01879918

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