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Zur Wirkung von Insulin, Carbutamid und 2-Desoxy-d-Glucose bei der akuten Äthylalkoholvergiftung der Ratte

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Zusammenfassung

Bei akuter Alkoholvergiftung der Ratte (2 ml Äthylalkohol 25% intraperitoneal pro kg Körpergewicht) wurde die Elimination des Alkohols aus dem Blut durch Insulin nicht beeinflußt. Carbutamid und 2-Desoxy-d-Glucose waren ebenfalls wirkungslos.

Summary

It has been demonstrated in animal experiments that in acute alcohol intoxication insulin does not affect the elimination of alcohol from the organism. Carbutamide and 2 desoxy-d-glucose do not have a similar effect either (2 ml aethylalcohol per kg body weight intraperitoneally). Based on these observations no close correlation between alcohol breakdown and carbohydrate metabolism can be assumed. Administration of insulin in acute alcohol intoxication does not seem to be justified.

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Authors and Affiliations

  1. Aus der II. Medizinischen Universitätsklinik und aus dem Gerichtlich-medizinischen Institut der Universität Budapest, Hungary

    Gabriel Pogátsa, Anton Káldor, Elisabeth Bellus & Endre Somogyi

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  1. Gabriel Pogátsa
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  2. Anton Káldor
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  3. Elisabeth Bellus
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  4. Endre Somogyi
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Pogátsa, G., Káldor, A., Bellus, E. et al. Zur Wirkung von Insulin, Carbutamid und 2-Desoxy-d-Glucose bei der akuten Äthylalkoholvergiftung der Ratte. Klin Wochenschr 43, 611–613 (1965). https://doi.org/10.1007/BF01879184

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