Transfer factor prevents relapses in herpes keratitis patients: A pilot study

Abstract

Transfer Factor is a dialysable moiety obtained from immune lymphocytes. It has been successfully used for the treatment of several viral infections including labial and genital herpes. In the present study, thirty-three patients with low immune response to HSV antigens and suffering from herpes ocular infections were orally treated with HSV-specific transfer factor (TF). Their relapse index was reduced from 20.1 before treatment to 0.51 after TF administration, with only 6/33 patients relapsing. Although this is not a placebo-controlled-randomized study, the results suggest that TF specific for HSV antigens may be efficacious for preventing relapses of ocular herpes infections as has been the case with genital and labial localisations.

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Abbreviations

CMI:

Cell-mediated immunity

CMV:

Cytomegalo-virus

EBV:

Epstein-Barr virus

HIV:

Human immunodeficiency virus

HK:

Herpes keratitis

HSV:

Herpes simplex virus

IRI:

Individual relapse index

KU:

Kerato-uveitis

LMT:

Leucocyte migration test

LST:

Lymphocyte stimulation test

MIF:

Migration inhibition factor

RHK:

Relapsing herpes keratitis

TF:

Transfer factor

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Correspondence to Dr. Dimitri Viza.

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Pizza, G., Meduuri, R., De Vinci, C. et al. Transfer factor prevents relapses in herpes keratitis patients: A pilot study. Biotherapy 8, 63–68 (1994). https://doi.org/10.1007/BF01878122

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Key words

  • Cell-mediated immunity
  • herpes
  • keratitis
  • uveitis
  • transfer factor