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Production of granulocyte colony-stimulating factor by head and neck carcinomas

  • Published:
Biotherapy

Abstract

Detectable levels of G-CSF by enzyme-linked immunosorbent assay (ELISA) were found in sera of 4 out of 15 patients with head and neck carcinomas. Also cells prepared from the tumors of these 4 patients secreted G-CSF. The supernatants of cells derived from all 15 patients did not contain granulocyte-monocyte CSF, monocyte CSF, tumor necrosis factor-α, transforming growth factor-β 1, epidermal growth factor, interleukin (IL)-1β and IL-6. These findings suggest that leukocytosis in patients with carcinomas might be due to the production of G-CSF by tumor cells.

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Abbreviations

CSF:

colony stimulating factor

EGF:

epidermal growth factor

ELISA:

Enzyme-linked immunosorbent assay

G:

granulocyte

GM:

granulocyte-monocyte

IL:

interluekin

M:

monocyte

TGF:

transforming growth factor

TNF:

tumor necrosis factor

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Authors and Affiliations

  1. Department of Otorhinolaryngology, Yokohama City University, School of Medicine, Fukuura 3-9, Kanazawa-ku, Yokohama, 236, Kanagawa, Japan

    Mamoru Tsukuda, Taro Nagahara, Tadayuki Yago & Hideki Matsuda

  2. Department of Biochemistry, Kanagawa Cancer Center, Nakao-cho 54-6, Asahi-ku, Yokohama, 241, Kanagawa, Japan

    Shunsuke Yanoma

Authors
  1. Mamoru Tsukuda
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  2. Taro Nagahara
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  3. Tadayuki Yago
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  4. Hideki Matsuda
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  5. Shunsuke Yanoma
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Tsukuda, M., Nagahara, T., Yago, T. et al. Production of granulocyte colony-stimulating factor by head and neck carcinomas. Biotherapy 6, 183–187 (1993). https://doi.org/10.1007/BF01878079

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  • DOI: https://doi.org/10.1007/BF01878079

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