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A recombinant human interleukin-1β protects adriamycin-induced toxicity

Adriamycin cardiotoxicity and interleukin-1

  • Published:
Biotherapy

Abstract

Pretreatment with recombinant human interleukin-1β (IL-1) protected normal BALB/c mice from the lethal effect adriamycin (ADM) of related to dose and frequency of administration. Posttreatment with IL-1 failed to protect. Neutrophil and platelet counts after the administration of ADM (16mg/kg) did not differ between the group with and that without IL-1 pretreatment, whereas lipid peroxide levels in the heart were reduced in the group pretreated with IL-1. It appears that the chemoprotection mechanism of IL-1 lies in the prevention of cardiotoxicity due to ADM-induced free radicals.

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Abbreviations

IL-1:

interleukin-1

ADM:

adriamycin

MDA:

malondialdehyde

MnSOD:

manganous superoxide dismutase

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Authors and Affiliations

  1. Department of Internal Medicine, Toyama Prefectural Central Hospital, Nishinagae 2-2-78, Toyama-shi, 930, Toyama, Japan

    Hirokazu Okumura M.D. & Takashi Yoshida

  2. Third Department of Internal Medicine, Kanazawa University School of Medicine, Kanazawa, Japan

    Hiroyasu Kaya, Sadaya Matano, Yoko Okabe, Shigeki Ohtake, Shinobu Nakamura & Tamotsu Matsuda

Authors
  1. Hirokazu Okumura M.D.
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  2. Takashi Yoshida
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  3. Hiroyasu Kaya
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  4. Sadaya Matano
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  5. Yoko Okabe
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  6. Shigeki Ohtake
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  7. Shinobu Nakamura
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  8. Tamotsu Matsuda
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Okumura, H., Yoshida, T., Kaya, H. et al. A recombinant human interleukin-1β protects adriamycin-induced toxicity. Biotherapy 7, 137–143 (1993). https://doi.org/10.1007/BF01877737

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  • DOI: https://doi.org/10.1007/BF01877737

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