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Sodium ditiocarb as adjuvant immunotherapy for high risk breast cancer: A randomized study

Abstract

Sixty-four patients with non metastatic high risk breast cancer were randomized in a double blind trial of adjuvant immunotherapy with sodium ditiocarb (DDC) versus placebo. All patients underwent prior surgery (mammectomy according to Patey) then adjuvant FAC chemotherapy +/- DDC. With a median follow-up of 5 years we observed 6 relapses and 5 deaths in DDC group; 13 relapses and 12 deaths in control group. At 6 years, overall survival is 81% in DDC group versus 55%. Disease free survival (DFS) is 76% in DDC group versus 55%. DDC associated to chemotherapy and locoregional treatment can improve survival and probably DFS in this high risk breast cancer subgroup.

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Abbreviations

DDC:

sodium ditiocarb

DFS:

disease free survival

OS:

overall survival

N:

node

FAC:

5 Fluorouracil, Adrianycin, Cyclopho-pharmide

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Dufour, P., Lang, J.M., Giron, C. et al. Sodium ditiocarb as adjuvant immunotherapy for high risk breast cancer: A randomized study. Biotherapy 6, 9–12 (1993). https://doi.org/10.1007/BF01877380

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  • DOI: https://doi.org/10.1007/BF01877380

Key words

  • adjuvant immunotherapy
  • breast cancer
  • ditiocarb sodium