Abstract
Chloroform should be considered as an obsolete preservative for pharmaceutical preparations, because of its toxicological implications and its physical instability. The effectiveness of possible alternatives for chloroform in three oral liquid pharmaceutical preparations was investigated, using a microbiological challenge test. Magnesium trisilicate mixture (British Pharmacopoeia) can be adequately preserved with methylparaben (2 g/l). Only insignificant amounts of methylparaben were absorbed by the solids present in the magnesium trisilicate mixture. Ferrous sulfate mixture (British Pharmacopoeia) can be preserved with a mixture of methylparaben (1.8 g/l) and propylparaben (0.2 g/l). Sorbic acid (1 g/l) is a suitable preservative for promethazine hydrochloride syrup.
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References
Reynolds JEF, editor. Martindale, the extra pharmacopoeia. 28th edition. London: The Pharmaceutical Press, 1982:745–6.
British Pharmacopoeia. London: Her Majesty's Stationery Office, 1988.
United States Pharmacopeia XXII. Rockville: United States Pharmacopeial Convention, 1990:1478–9.
Vanhaecke E, Remon JP, Pijck J, Aerts R, Herman J. A comparative study of the effectiveness of preservatives in twelve antacid suspensions. Drug Dev Ind Pharm 1987;13:1429–46.
Van Doorne H. Interactions between preservatives and pharmaceutical components. In: Denyer S, Baird R, editors. Guide to microbiological control in pharmaceuticals. Chichester: Ellis Horwood, 1990:274–91.
Tromp ThFJ. Various aspects of the microbiological quality of pharmaceutical preparations [dissertation]. Groningen: University of Groningen, 1983.
Van Doorne H, Wieringa NF, Bosch EH, De Meijer R. The suitability of some preservatives in chloroquine phosphate syrup. Pharm Weekbl Sci 1988; 10:170–2.
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van Doorne, H., Leijen, J.B. The preservation of some oral liquid preparations. Pharm World Sci 16, 18–21 (1994). https://doi.org/10.1007/BF01870934
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DOI: https://doi.org/10.1007/BF01870934