Skip to main content
SpringerLink
Log in

Comparison of ion current noise predicted from different models of the sodium channel gating mechanism in nerve membrane

  • Published:
The Journal of Membrane Biology Aims and scope Submit manuscript

Summary

The theoretical power density spectrumS(f) of ion current noise is calculated from several models of the sodium channel gating mechanism in nerve membrane. Sodium ion noise experimental data from the frog node of Ranvier [Conti, F.,et al. (1976),J. Physiol. (London) 262:699] is used as a test of the theoretical results. The motivation for recent modeling has been evidence for a coupling between sodium activation and inactivation from voltage clamp data. The two processes are independent of one another in the Hodgkin and Huxley (HH) model [Hodgkin, A.L., Huxley, A.F. (1952),J. Physiol. (London) 117:500] The noise data is consistent with HH, as noted by Contiet al. (1976). The theoretical results given here appear to indicate that only one case of coupling models is also consistent with the noise data.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Armstrong, C.M., Bezanilla, F. 1977. Inactivation of the sodium channel. II. Gating current experiments.J. Gen. Physiol. 70:567

    PubMed  Google Scholar 

  • Bezanilla, F., Armstrong, C.M. 1975. Properties of the sodium channel gating current.Cold Spring Harbor Symp. Quant. Biol. 40:297

    Google Scholar 

  • Bezanilla, F., Armstrong, C.M. 1977. Inactivation of the sodium channel. I. Sodium Current Experiments.J. Gen. Physiol. 70:549

    PubMed  Google Scholar 

  • Chen, Y.D., Hill, T.L. 1973. Fluctuations and noise in kinetic systems. Application to K+ channels in the squid axon.Biophys. J. 13:1276

    PubMed  Google Scholar 

  • Chiu, S.Y. 1976. Observations on sodium channel inactivation in frog nerve.Biophys. J. 16:24a (Abstr.)

    Google Scholar 

  • Clay, J.R. 1977. A comparison of ion current noise predicted from diffrent kinetic models of the sodium channel.Biophys. J. 17:12a (Abstr.)

    Google Scholar 

  • Connor, J.A. 1976. Sodium current inactivation in crustacean axons.Biophys. J. 16:24a (Abstr.)

    Google Scholar 

  • Conti, F., DeFelice, L.J., Wanke, E. 1975. Potassium and sodium ion current noise in the membrane of the squid giant axon.J. Physiol. (London) 248:45

    Google Scholar 

  • Conti, F., Hille, B., Neumcke, B., Nonner, W., Stämpfli, R. 1976. Measurement of the conductance of the sodium channel from current fluctuations at the node of Ranvier.J. Physiol. (London) 262:699

    Google Scholar 

  • Fitzhugh, R. 1965. A kinetic model of the conductance changes in nerve membrane.J. Cell. Comp. Physiol. 66:111

    Google Scholar 

  • Frankenhaeuser, B., Hodgkin, A.L. 1957. The action of calcium on the electrical properties of squid axons.J. Physiol. (London) 137:218

    Google Scholar 

  • Goldman, L., Schauf, C.L. 1973. Quantitative description of sodium and potassium currents and computed action potentials inMyxicola giant axons.J. Gen. Physiol. 61:361

    PubMed  Google Scholar 

  • Guttman, R., Barnhill, R. 1970. Oscillation and repetitive firing in squid axons. Comparison of experiments with computations.J. Gen. Physiol. 55:104

    PubMed  Google Scholar 

  • Hildebrand, F.B. 1965. Methods of Applied Mathematics. Prentice Hall, Englewood Cliffs

    Google Scholar 

  • Hill, T.L., Chen, Y.D. 1972. On the theory of ion transport across the nerve membrane. IV. Noise from the open-close kinetics of K channels.Biophys. J. 12:948

    PubMed  Google Scholar 

  • Hodgkin, A.L., Huxley, A.F. 1952. A quantitative description of membrane current and its application to conduction and excitation in nerve.J. Physiol. (London) 117:500

    Google Scholar 

  • Hodgkin, A.L., Keynes, R.D. 1955. Active transport of cations in giant axons fromSepia andLoligo.J. Physiol. (London) 128:28

    Google Scholar 

  • Huxley, A.F. 1957. Ion movements during nerve activity.Ann. N.Y. Acad. Sci. 81:221

    Google Scholar 

  • Jakobsson, E. 1978. A fully coupled transient excited state model for the sodium channel. I. Conductance in the voltage clamped case.J. Math. Biol. (in press)

  • Moore, J.W., Cox, E.B. 1976. A kinetic model for the sodium conductance in squid axon.Biophys. J. 16:171

    PubMed  Google Scholar 

  • Neher, E., Sakmann, B. 1976. Single channel currents recorded from membrane of denervated frog muscle fibres.Nature (London) 260:799

    Google Scholar 

  • Neher, E., Stevens, C.F. 1977. Conductance fluctuations and ionic pores in membranes.Annu. Rev. Biophys. Bioeng. 6:345

    PubMed  Google Scholar 

  • Oxford, G.S., Pooler, J.P. 1975. Selective modification of sodium channel gating in lobster axons by 2,4,6, trinitrophenol. Evidence for two inactivation mechanism.J. Gen. Physiol. 66:765

    PubMed  Google Scholar 

  • Peganov, E.M. 1973. Kinetics of sodium channel inactivation in the frog Ranvier node.Bull. Exp. Biol. Med. 76:1254

    Google Scholar 

  • Sigworth, F.J. 1977. Sodium channels in nerve apparently have two conducting states.Nature (London) 270:265

    Google Scholar 

  • Stevens, C.F. 1972. Inferences about membrane properties from electrical noise measurements.Biophys. J. 12:1028

    Google Scholar 

  • Wang, M.C., Uhlenbeck, G.E. 1954. On the theory of Brownian motion.In: Selected Papers on Noise and Stochastic Processes. N. Wax, editor. Dover, New York

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Anatomy, Emory University, 30322, Atlanta, Georgia

    John R. Clay

Authors
  1. John R. Clay
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Clay, J.R. Comparison of ion current noise predicted from different models of the sodium channel gating mechanism in nerve membrane. J. Membrain Biol. 42, 215–227 (1978). https://doi.org/10.1007/BF01870359

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01870359

Keywords

Search

Navigation