The Journal of Membrane Biology

, Volume 42, Issue 4, pp 331–343 | Cite as

Studies on chloride permeability of the skin ofLeptodactylus ocellatus: II. Na+ and Cl effect of inward movements of Cl

  • C. A. Rotunno
  • M. V. Ques-von Petery
  • M. Cereijido


At low concentration (1mm) of Cl in the outer solution, the influx of chloride through the isolated skin (J 13 Cl ) of the South American frogLeptodactylus ocellatus (L.) seems to be carried by two mechanisms: (i) a passive one that exhibits the characteristics of an exchange diffusion process, and (ii) an active penetration. Studies of the influx and efflux of chloride (J 13 Cl andJ 31 Cl ) indicate, that the presence of a high (107mm) concentration of Cl in the outer solution activates the translocation of this ion through the cells. Studies of the unidirectional flux of Cl across the outer barrier (J 12 Cl ) indicate that Na+ out stimulates the penetration of Cl at this level. Cl out, in turn, stimulates, theJ 12 Na , but this effect is only detected at low concentrations of Na+ out.


Chloride Human Physiology Diffusion Process Outer Solution Exchange Diffusion 
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Copyright information

© Springer-Verlag New York Inc 1978

Authors and Affiliations

  • C. A. Rotunno
    • 1
    • 2
  • M. V. Ques-von Petery
    • 1
    • 2
  • M. Cereijido
    • 1
    • 2
  1. 1.Department of BiophysicsAlbert Einstein Center of Medical Research (CIMAE)Buenos AiresArgentina
  2. 2.Centro de Investigaciones y Estudios Avanzados del I.P.N.México 14Mexico

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