The Journal of Membrane Biology

, Volume 19, Issue 1, pp 277–303 | Cite as

Statistical analysis of alamethicin channels in black lipid membranes

  • Günther Boheim
Article

Summary

Pore formation of alamethicin has been studied by the analysis of steadystate fluctuations of single-pore conductances. An aggregation model is proposed where transitions to the next higher or lower pore state occur by uptake or release of one monomer. It is assumed that alamethicin forms an elongated loop in the bilayer. The main voltage-dependent step is the insertion of this monomer into the membrane after complexation with a cation. This mechanism is equivalent to dipole orientation in an electric field. Pore formation is restricted by the energy required to enlarge the channel in the membrane.

Keywords

Lipid Human Physiology Lipid Membrane Pore Formation Aggregation Model 

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Copyright information

© Springer-Verlag New York Inc. 1974

Authors and Affiliations

  • Günther Boheim
    • 1
  1. 1.Fachbereich BiologieUniversität KonstanzKonstanzGermany

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