Summary
The effects of the calcium-entry blocker nicardipine on brachial hemodynamics were studied in 22 patients (18 male, 4 female) with essential hypertension, who were treated with 20 mg tid for 1 year. Compliance, characteristic impedance, vascular resistances, and tangential tension were measured before treatment and after 1, 3, and 12 months of treatment by an automatic recording from a B-mode, high-resolution, real-time scanner and pulsed Doppler velocimetry for the calculation of the flow volume. We observed statistically significant variations in compliance and impedance after 1 month (3.21±0.59 dyn−1 cm4 10−7 vs. 1.26±0.16 dyn−1 cm4 10−7 and 50.6±4.7 dyn s cm−5102 vs. 91.4 ±7.3 dyn s cm−5 102, respectively; mean±SEM; p<0.001), while tangential tension was significantly reduced after only 3 months (23.2±2.2 mmHg vs. 25.4±2.3 mmHg cm; p<0.05). The correlation between variations in mean blood pressure and in the hemodynamic parameters studied remained statistically significant throughout the study. Nicardipine improved the parameters of large-artery hemodynamics that favor a normal systolic pulse.
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References
Folkow B. Physiological aspects of primary hypertension.Physiol Rev 1982; 62:347–504.
Mulvany MJ. The structure of the resistance vasculature in essential hypertension.J Hypertens 1987; 5:129–136.
Folkow B. Structure and function of the arteries in hypertension.Am Heart J 1987; 114:938–948.
O'Rourke MF.Arterial Function in Health and Disease. London: Churchill & Livingstone, 1982.
Safar ME, London GM. Arterial and venous compliance in sustained essential hypertension.Hypertension 1987; 10:133–139.
Guazzi MD, Polese A, Fiorentini C, et al. Treatment of hypertension with calcium antagonists, review.Hypertension 1983; 5:1185–1190.
Levenson J, Simon AC, Bouthier J, et al. The effect of acute and chronic nicardipine therapy on forearm arterial hemodynamics in essential hypertension.Br J Clin Pharmacol 1985; 20:107S-113S.
Farrar DJ, Green HD, Bond MG, et al. Aortic pulse wave velocity, elasticity, and composition in a nonhuman primate model of atherosclerosis.Circ Res 1978; 43:52–62.
McDonald DA. Wave reflection. In:Blood Flow in Arteries. 2nd ed. Baltimore: Williams & Wilkins, 1974:309–350.
Tarazi RC. The role of the heart in hypertension.Clin Sci 1982; 63 (Suppl 8):347s-358s.
Levenson J, Safar ME, Simon AC, et al. Systemic and arterial hemodynamic effects of nifedipine (20 mg) in mild-to-moderate hypertension.Hypertension 1983; 5 (Suppl 5):V57-V60.
Ventura HO, Messerli FH, Oigman W, et al. Immediate hemodynamic effects of a new calcium-channel blocking agent (nitrendipine) in essential hypertension.Am J Cardiol 1983; 51:783–786.
Safar ME, Simon AC, Levenson J, et al. Hemodynamic effects of diltiazem in hypertension.Circ Res 1983; 52 (Suppl I):I169-I173.
Jaffe MD. High-flow dilatation.Lancet 1981; 1:1237–1238.
Scriabine A, Kazda S, Garthoff B, Nickerson PA. Pharmacological basis for use of calcium channel antagonists in hypertension.Angiology 1988; 1:94–99.
Luscher TF, Raij L, Vanhoutte PM. Endothelium-dependent vascular responses in normotensive and hypertensive Dahl rats.Hypertension 1987; 9:157–163.
Peach MJ, Singer HA. The endothelium in hypertension. In: Edwards CRW, Carey RM (eds.)Essential Hypertension as an Endocrine Disease. London: Butterworth & Co. 1985:212–232.
Fitchett DH. Forearm arterial compliance: A new measure of arterial compliance?Cardiovasc Res 1984; 18:651–656.
Safar ME, Bouthier JA, Levenson JA, et al. Peripheral large arteries and the response to antihypertensive treatment.Hypertension 1983; 5 (Suppl III):III63-III68.
Ventura H, Messerli FH, Oigman W, et al. Impaired systemic arterial compliance in borderline hypertension.Am Heart J 1984; 108:132–136.
Owens GK, Schwartz SM. Alterations in vascular smooth muscle mass in the spontaneously hypertensive rat: Role of cellular hypertrophy, hyperploidy, and hyperplasia.Circ Res 1982; 51:280–289.
Owens GK, Rabinovitch PS, Schwartz SM. Smooth muscle cell hypertrophy versus hyperplasia in hypertension (polyploidy spontaneously hypertensive rat cell cycle).Proc Natl Acad Sci USA 1981; 78:7759–7763.
Barrett TB, Sampson P, Owens GK, et al. Polyploid nuclei in human artery wall smooth muscle cell.Proc Natl Acad Sci USA 1983; 80:882–885.
Safar ME, London GM, Bouthier JA, et al. An indirect approach for the study of the elastic modulus of the brachial artery in men with essential hypertension.Cardiovasc Res 1986; 20:563–567.
Rorive GL, Carlier PG, Foidart JM. The structural responses of the vascular wall in experimental hypertension. In: Zanchetti A, Tarazi RC (eds.)Pathophysiology of Hypertension: Cardiovascular Aspects. Amsterdam: Elsevier Science, 1986:427–454.
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Arosio, E., Pancera, P., Arcaro, G. et al. Effects of long-term nicardipine treatment on hemodynamics of large arteries in essential hypertension. Cardiovasc Drug Ther 3, 835–839 (1989). https://doi.org/10.1007/BF01869568
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DOI: https://doi.org/10.1007/BF01869568