Summary
Growth ofMicroccoccus lysodeikticus in the presence of pantoyl lactone brings about both qualitative and quantitative changes in cell membrane lipids. Significant amounts of the two major phospholipids (phosphatidylglycerol and diphosphatidylglycerol) are converted to lyso forms; the largest conversion occurs in the phosphatidylglycerol. In addition, amounts of several phospholipid fatty acids are changed. Physical alteration of the cell membrane can be demonstrated using differential scanning calorimetry. Although growth and transport are significantly inhibited when pantoyl lactone is present, cells possessing altered cell membrane phospholipids and phospholipid fatty acids, brought about by growth in the presence of pantoyl lactone, transportd-alanine,l-glutamic andl-aspartic acid normally when washed free of the pantoyl lactone.
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Johnson, J.H., Grula, E.A., Staerkel, R. et al. Modification of cell membrane lipids inMicrococcus lysodeikticus induced by pantoyl lactone. J. Membrain Biol. 56, 49–53 (1980). https://doi.org/10.1007/BF01869351
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DOI: https://doi.org/10.1007/BF01869351