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Adsorptionsverfahren zur Bestimmung von Arzneimitteln in biologischem Material

The adsorption methods in the analysis of drugs in biological materials

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Summary

The usefulness of adsorbents (XAD-resin, charcoal and ion exchange resins) in the toxicological analysis is investigated and compared with the wellknown extraction methods. Although solid adsorbents are convenient in their application for urine samples, solvent extraction is much superior in the separation of acidic and basic compounds, in the recovery of drugs and in the universal application to all types of biological samples (organ extracts). In any case it is suggested to consider critically the use of adsorbents.

Zusammenfassung

Die Brauchbarkeit von Adsorbentien (XAD-Harze, Aktivkohle, Ionenaustauscher) für die toxikologische Analyse wurde untersucht und der herkömmlichen Extraktionsmethode gegenübergestellt. Obwohl Adsorptionsmittel bei der Untersuchung von Harnproben bequem anzuwenden sind, können die Extraktionsmethoden sowohl hinsichtlich ihrer Fähigkeit, in saure und basische Fraktionen zu trennen, als auch in der besseren Ausbeute und der Anwendung für alle Untersuchungsmaterialien (besonders Organextrakte) nicht ersetzt werden.

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Literatur

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Authors and Affiliations

  1. Institut für gerichtliche Medizin der Universität, Sensengasse 2, A-1090, Wien, Österreich

    G. Machata & W. Vycudilik

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  1. G. Machata
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  2. W. Vycudilik
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Machata, G., Vycudilik, W. Adsorptionsverfahren zur Bestimmung von Arzneimitteln in biologischem Material. Z Rechtsmed 74, 43–46 (1974). https://doi.org/10.1007/BF01869183

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  • DOI: https://doi.org/10.1007/BF01869183

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