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The Journal of Membrane Biology

, Volume 50, Issue 1, pp 1–14 | Cite as

Microtubules inside the plasma membrane of squid giant axons and their possible physiological function

  • Gen Matsumoto
  • Hikoichi Sakai
Article

Summary

The effects of application of the microtubule-disassembling reagents to squid giant axons upon resting potential, the height of the propagated action potential, and the threshold to evoke action potential were studied using colchicine, podophyllotoxin, vinblastine, griseofulvin, sulfhydryl reagents including NEM, diamide, DTNB and PCMB, and Ca2+ ions. At the same time, the effects of concentrations of K halides and K glutamate on the above physiological properties were studied in comparison within vitro characteristics of microtubule assembly from purified axoplasmic tubulin.

It was found that there was good correlation between conditions supporting maintenance of membrane excitability and microtubule assembly. The experiments suggest that associated with the internal surface of the plasma membrane there are microtubules which regulate in part both resting and action potentials.

Keywords

Plasma Membrane Glutamate Colchicine Physiological Function Halide 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag New York Inc. 1979

Authors and Affiliations

  • Gen Matsumoto
    • 1
    • 2
  • Hikoichi Sakai
    • 1
    • 2
  1. 1.Optoelectronics SectionElectrotechnical LaboratoryTanashi, TokyoJapan
  2. 2.Department of Biophysics and Biochemistry, Faculty of ScienceUniversity of TokyoTokyoJapan

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