The Journal of Membrane Biology

, Volume 3, Issue 1, pp 223–240 | Cite as

Discrimination between monovalent and divalent cations by hydrophobic solvent-saturated membranes containing fixed negative charges

  • A. Ilani


Cellulose acetate-nitrate filters were saturated with hydrophobic solvent and interposed between various aqueous solutions. The membranes thus formed are cation permselective. The discrimination between a monovalent cation such as K+ and the alkaline earth group divalent cations is very sharp. The discrimination ratio is at least a few thousand times in favor of the monovalent cation. A major part of this discrimination is caused by the very low mobility of the divalent cation within the membrane compared with that of the monovalent cation. The remainder of the discrimination is caused by the selectivity of the membranes which prefer monovalent to divalent cations. There is a clear discrepancy between Ba++ diffusibility and mobility within, the membrane. This implies that Ba++ may move within the hydrophobic membrane as a neutral complex. Some similarity with natural biological membranes is indicated.


Cellulose Aqueous Solution Human Physiology Negative Charge Major Part 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Bonner, O. D., Smith, L. L. 1957. A selectivity scale for some divalent cations on Dowex 50.J. Phys. Chem. 61:326.Google Scholar
  2. 2.
    Cranck, J. 1956. The Mathematics of Diffusion. Clarendon Press, Oxford.Google Scholar
  3. 3.
    Eisenman, G. 1962. Cation selective glass electrodes and their mode of operation.Biophys. J. 2 suppl:259.PubMedGoogle Scholar
  4. 4.
    Goldman, D. E. 1943. Potential, impedance and rectification in membranes.J. Gen. Physiol. 27:37.CrossRefGoogle Scholar
  5. 5.
    Helfferich, F. 1962. Ion Exchange. p. 156. McGraw-Hill, New York.Google Scholar
  6. 6.
    Hodgkin, A. L., Katz, B. 1949. The effect of sodium on the electrical activity of the giant axon of the squid.J. Physiol. 108:37.Google Scholar
  7. 7.
    — Keynes, R. D. 1957. Movements of labelled calcium in squid giant axons.J. Physiol. 138:253.PubMedGoogle Scholar
  8. 8.
    Ilani, A. 1965. Ion discrimination by “Millipore” filters saturated with organic solvents. I. Cation selectivity, mobility and relative permeability of membranes saturated with bromobenzene.Biochim. Biophys. Acta 94:405.Google Scholar
  9. 9.
    — 1966a. Ion exchange membranes saturated with hydrophobic solvents.Israel J. Chem. 4:105.Google Scholar
  10. 10.
    — 1966b. Interaction between cations in hydrophobic solvent-saturated filters containing fixed negative charges.Biophys. J. 6:329.PubMedGoogle Scholar
  11. 11.
    — Tzivoni, D. 1968. Hydrogen ions in hydrophobic membranes.Biochim. Biophys. Acta 163:429.PubMedGoogle Scholar
  12. 12.
    Macey, H. H. 1940. Clay-water relationship.Proc. Phys. Soc. 52:625.Google Scholar
  13. 13.
    Soldano, B. A., Boyd, G. E. 1953. Self-diffusion of cations in heteroionic cation exchangers.J. Amer. Chem. Soc. 75:6107.Google Scholar

Copyright information

© Springer-Verlag New York Inc. 1970

Authors and Affiliations

  • A. Ilani
    • 1
  1. 1.Department of PhysiologyHebrew University-Hadassah Medical SchoolJerusalemIsrael

Personalised recommendations