Journal of Biological Physics

, Volume 15, Issue 3, pp 43–55 | Cite as

An additional circulatory system: Vascular-Interstitial closed electric circuits (VICC)

  • Björn E. W. Nordenström
Article

Abstract

The construction and activation of a previously described additional circulatory system for long-distance transport in tissue is summarized. Metabolism or injury produces electrochemical polarization of tissue. This driving force produces exchange of material by electrophoresis and dielectrophoresis in tissue and cellular matrices with fixed surface charges. These transports are described over vascular-intersititial closed electric circuits (VICC) because blood vessels function as relatively insulated conducting cables and connect with the conducting tissue fluids over capillaries. Necessary electron tranfer takes place at sites of segmental capillary contractions by the superimposed electric field via globular proteins known to exchange electrons in the endothelial cellular membranes. The effect of field-activated VICC is here demonstrated by accumulation of granulocytes in vivo as an electrophoretic process, which gives a mechanistic and energetic logical explanation of so-called leukotaxis.

Keywords

Polymer Statistical Physic Blood Vessel Electrophoresis Surface Charge 

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References

  1. 1.
    Öjteg, G. 1986.Acta Univ. Upsalien. 32.Google Scholar
  2. 2.
    Nordenström, B.E.W. 1983.Biologically Closed Electric Cirucuits: Clinical, Experimental and Theoretical Evidence for an Additional Circulatory System. Nordic Medical Pulications: Stockholm.Google Scholar
  3. 3.
    Nordenström, B. 1971.Acta Radiol Diagn. 11, 1–16.Google Scholar
  4. 4.
    Nordenström, B. 1974,Int. Res. Commun. System. Med Sci. 2 1666.Google Scholar
  5. 5.
    Nordenström, B. 1978.Int. Res. Commun. System. Med. Sci. 6, 537.Google Scholar
  6. 6.
    Nordenström, B.From Premier cours international Montpelerain de radiodiagnostic mammaire. Montpellier, France 24–27 March 1981; pp 23–24.Google Scholar
  7. 7.
    Hellström, L.G. 1983.Elteknik 19, 6–10.Google Scholar
  8. 8.
    Nordenström, B. 1984.J. Bioelec. 3, 137–153.Google Scholar
  9. 9.
    Kumazaki, T. 1984. Medical English1, 6–18.Google Scholar
  10. 10.
    Nordenström, B.E.W. 1985.Ann Radiol 28, 128–129.Google Scholar
  11. 11.
    Nordenström, B.E.W. 1985.Am. J. Roentgenol. 145, 447–467.Google Scholar
  12. 12.
    Nordenström, B.E.W. 1986.In Neoplasie del torace. Veronesi, R.; Pezzuoli, G.; Ravasi, G.; Santoro, O., Eds. Casa Editrice Ambrosiana: Milano pp. 219–226.Google Scholar
  13. 13.
    Bockris, O'M.J.: Dražić, D.. 1972,Electro-chemical Science. Taylor and Francis Ltd.: London.Google Scholar
  14. 14.
    Farquhar, M.G. 1961.Angiology 12, 270–292.Google Scholar
  15. 15.
    Elfvin, L. G.J. Ultrastruct. Res. 1965.12, 687–704.CrossRefGoogle Scholar
  16. 16.
    Rhodin, J.A.G. 1962.J. Ultrastruct. Res. 6, 171–185.CrossRefGoogle Scholar
  17. 17.
    Sjöstrand, F.S.; Elfvin, L.G. 1962.J. Ultrastruct. Res. 7, 504–534.CrossRefGoogle Scholar
  18. 18.
    Robertson, J.D. 1964. InCellular Membranes in Development, Locke, M., Ed. Academic Press. New York, London, pp. 1–81.Google Scholar
  19. 19.
    Sjöstrand, F.S. 1967Protoplasma 63, 248–261.CrossRefGoogle Scholar
  20. 20.
    Singer, S.J. 1971. InStructure and Functionof Biological Membranes, Academic Press: New York, pp. 146–217.Google Scholar
  21. 21.
    Sjöstrand, F.S. 1971. InCell membranes. Biological and Pathological Aspects, Richter, G.W.; Scarpelli, D.G., eds. Williams and Wilkins: Baltimore, pp. 1–29.Google Scholar
  22. 22.
    Singer, S.J.; Nicolson, G.L. 1972.Science,175, 720–731.PubMedGoogle Scholar
  23. 23.
    Rhodin, J.A.G. 1924.Histology. A Text and Atlas. Oxford University Press: New York, London, Toronto, pp. 272–292.Google Scholar
  24. 24.
    Nicholls, P. 1963.In The Enzymes. Boyer, P.D.: Hardy, H.; Myrbck, K. Eds. Academic Press; New York, London,8, 3–40.Google Scholar
  25. 25.
    Lenard, J.; Singer, S.J. 1966.Proc. Nat. Acad. Sci. 56, 1828–1835.Google Scholar
  26. 26.
    Puszkin, S.; Nicklas, W.J.; Berl S. 1972.J. Neurochem. 19, 1319–1333.Google Scholar
  27. 27.
    Berl, S.; Puszkin, S.; Nicklas, W. J. 1973.Science 179, 441–446.Google Scholar
  28. 28.
    Stebbings, H.; Hyams, J.S. 1979.Cell Motility. Longmans: London, New York, p. 7.Google Scholar
  29. 29.
    Zimmermann, K.W. 1923.Z. Anat. Entwicklungsgesch. 68, 3.Google Scholar
  30. 30.
    Mitchell, P.; Moyle, J. 1956.Disc. Faraday Soc. 21, 258–265.CrossRefGoogle Scholar
  31. 31.
    Nicholls, D. 1984. InBioenergetics: New Comprehensive Biochemistry, Ernster, L. Ed. Vol. 9. Elsevier. Amsterdam, New York, Oxford,9; 29–48.Google Scholar
  32. 32.
    Szent-Györgyi, A. 1941.Science 93, 609–611.Google Scholar
  33. 33.
    Cope, F.W. 1963.Arch. Biochem. Biophys. 103, 352–365.CrossRefGoogle Scholar
  34. 34.
    Cope, F.W. 1964.Proc. Nat. Acad. Sci. U.S.A. 51, 809–810.Google Scholar
  35. 35.
    Cope, F.W., 1965.Bull. Math. Biophys. 27, 237–252.Google Scholar
  36. 36.
    Trukhan, E. M., 1966.Biofizika,11, 412–419Google Scholar
  37. 37.
    Straub, K.D. 1967.Semiconduction in Certain Proteins. Ph. D. thesis, Duke University, Durham, NC, USA.Google Scholar
  38. 38.
    Jaklevic, R.C.; Lambe, J. 1969.In Tunneling Phenomena in Solids, Burstein, E.: Lundquist, S. Eds. Plenum Press: New York, pp. 243–253.Google Scholar
  39. 39.
    Rosenberg, B.; Postow, E. 1969.Ann. N. Y. Acad. Sci. 158, 161–190.Google Scholar
  40. 40.
    Pethig, R. 1943.J. Biol. Phys. 1, 193–214.Google Scholar
  41. 41.
    Pilla, A.A. 1974.Ann. N. Y. Acad. Sci. 238, 149–170.Google Scholar
  42. 42.
    Keilin, D. 1925.Proc. Roy. Soc. B98, 312–339.Google Scholar
  43. 43.
    Keilin, D.; King, T.E. 1958.Nature 8, 1520–1522.Google Scholar
  44. 44.
    Mitchell, P. 1966.Chemiosmotic Coupling in Oxidative and Photosynthetic Phosphorylation. Glynn Research Bodmin: Cornwall, England.Google Scholar
  45. 45.
    Malmsten, C.L.; Palmblad, J.; Udén, A.M.; Rådmark, O.; Engstedt, L.; Samuelsson, B. 1980.Acta Physiol. Scand. 110, 449–451.Google Scholar
  46. 46.
    Reed, L.; Meyrick, B. 1980 InMetabolic Activities of the Lung, Porter, R.; Whalen, J., Eds., Ciba Foundation Symposium 78, Excerpta Medica; Amsterdam, pp. 37–61.Google Scholar

Copyright information

© New Forums Press, Inc. 1987

Authors and Affiliations

  • Björn E. W. Nordenström
    • 1
  1. 1.Department of Diagnostic RadiologyKarolinska HospitalStockholmSweden

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