Journal of Biological Physics

, Volume 13, Issue 2, pp 43–47 | Cite as

Electrochemical interactions between some beta-lactam antibiotics and aminoglycoside antibiotics

  • G. M. Eckert
  • F. Gutmann
  • H. Keyzer


Complexation reactions between the two aminoglycosides tobramycin and gentamycin and the two beta-lactam antibiotics carbenicillin and ticarcillin were studied conductimetrically, in aqueous solution. Carbenicillin and gentamycin form a 2∶1 adduct in which about 75% of the antibiotics are bound. Likewise, carbenicillin and tobramycin form a 2∶1 adduct binding about 67% of its components. Tobramycin and ticarcillin also interact, but weakly, binding about 12% of the adduct components. Only a trace of adduct formation was observed between cephalothin and gentamycin and between cephalothin and tobramycin. Cephalothin did not interact with carbenicillin. It appears that the adsorption behavior of the aminoglycosides differs considerably from that of the beta-lactams.


Polymer Aqueous Solution Statistical Physic Adduct Aminoglycosides 
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Copyright information

© New Forums Press, Inc. 1985

Authors and Affiliations

  • G. M. Eckert
    • 1
  • F. Gutmann
    • 2
  • H. Keyzer
    • 3
  1. 1.Clinical PharmacologyThe Sydney HospitalSydneyAustralia
  2. 2.Department of ChemistryTexas A&M UniversityCollege StationUSA
  3. 3.Department of Chemistry and BiochemistryCalifornia State UniversityLos AngelesUSA

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