Summary
The electrophysiologic effects of xamoterol were studied in ten patients with electrophysiologic evidence of sinus node dysfunction. A significant shortening of mean sinus cycle length, maximal corrected sinus-node recovery time, and the mean of the three longest corrected sinus-node recovery times was observed after intravenous administration of 0.1 mg/kg of xamoterol. The atrioventricular (AV) conduction time and the effective and functional refractory periods of the AV node were shortened as the effective refractory period of the atrium. These effects suggest that xamoterol could be tried safely for the treatment of patients with moderate symptoms due to sinus-node disease.
Similar content being viewed by others
References
Conde CA, Leppo J, Lipski J, et al. Effectiveness of pacemaker treatment in the bradycardia-tachycardia syndrome. Am J Cardiol 1973;32:209.
Furman S. Cardiac pacing and pacemakers. Indications for pacing brady-arrhythmias.Am Heart J 1977;93:523
Rasmussen K. chronic sinus node disease: Natural course and indications for pacing.Eur Heart J 1981;2:455.
Strauss H, Gilbert M, Svenson R, et al. Electrophysiologic effects of propranolol on sinus node function in patients with sinus node dysfunction.Circulation 1976;54:452.
Narula O, Vasquez M, Shantha N et al. Effect of propranolol on normal and abnormal sinus node function. In: Bonke F, ed.The sinus node. Dordrecht: Martinus Nijhoff, 1978:112.
Wit A, Hoffman B, Rosen M. Electrophysiology and pharmacology of cardiac arrhythmias in cardiac electrophysiologic effects of β-adrenergic, receptor stimulation and blockade.Am Heart J 1975.;90:795.
Hombach V, Braun V, Hopp H, et al. Electrophysiological effects of cardioselective and non-cardioselective betaadrenoceptor blockers with and without ISA at rest and during exercise.Br J Clin Pharmacol 1982;13:285S.
Bittinger S, Smith S, Beta-adrenoceptor, antagonists increase sinus arrhythmia, a vagotonic effect.Br J Clin Pharmacol 1986;22:691.
Fitcha P, Tiso B, Meisner W, et al. The effect of sympathomimetic activity of beta-adreno-receptor blockers on circadian heart rate.Br J Clin Pharmacol 1982;13:211S.
Leclercq J, Rosengarten M, Kural S, et al. Effects of intrinsic sympathetic activity of beta blockers on SA and AV nodes in man.Eur J Cardiol 1981;12:367.
de Marneffe M, Ewalenko M, Englert M. Treatment of chronic atrial fibrillation: A comparison between digitalis alone and a combination of digitalis and beta-blocking agents.Neu Trends in Arrhythmias 1985;I:91.
Tseu F, Morley C, Mackintosh A. Xamoterol, an oral agent for the treatment of sinoatrial disease?Br Heart J 1985; 53:88.
Viersma J, Van Den Berg M, Van Gilst, et al. Intrinsic sympathomimetic activity (ISA) of pindolol in patients with sinus node dysfunction.Eur Heart J 1986;7:42.
de Marneffe M, Haardt R, Melot C, et al. Beta-blocking agent with high intrinsic sympathomimetic activity for treatment of sick sinus syndrome (abstract).Pace 1987; 10:667.
Mandel W, Hayakawa H, Danzig R et al. Evaluation of sino-atrial node function in man by overdrive suppression.Circulation 1971;44:59.
Reiffel J, Gang E, Bigger J. Sinus node recovery time related to pace cycle length in normals and patients with sinoatrial dysfunction.Am Heart J. 1982;104:746.
Strauss H Saroff A, Bigger J, et al. Premature atrial stimulation as a key to the understanding of sinoatrial conduction in man.Circulation 1973;47:86.
Ikäheimo M, Takkunen J. The effects of beta1-adrenoceptor partial agonist ICI 118.587 on left ventricular function in patients with coronary heart disease.Int J Cardiol 1984; 5:339.
Jennings G, Bobik A, Oddie C, et al. Cardioselectivity, kinetics, hemodynamics and metabolic effects of xamoterol.Clin Pharmacol Ther 1984;35:594.
Jordan J, Yamaguchi I, Mandel W. Studies on the mechanism of sinus node dysfunction in the sick sinus syndrome.Circulation 1978;57:217.
Kang, P, Gomes J, El-Sherif N. Differential effects of functional autonomic blockade on the variables of sinus nodal automaticity in sick sinus syndrome.Am J Cardiol 1982; 49:273.
de Marneffe M, Waterschoot P, melot C, et al. Electrophysiology of the normal sinus node.J Electrophysiol 1988; 2:155.
Engel T, Leddy C, Del Gonzalez A, et al. Electrophysiologic effects of hydralazine on sinoatrial function in patients with sick sinus node syndrome.Am J Cardiol 1978;41:763.
Weiss A, Rod J, Gotsman M, et al. Hydralazine in the management of symptomatic sinus bradycardia.Eur J Cardiol 1981;12:261.
Lewis S, Rozenman Y, Merdler A, et al.., Chronotropic effect of hydralazine and its mechanism in symptomatic sinus bradycardia.Am J Cardiol 1987;59:93.
Benditt D, Benson W, Kreitt J et al. Electrophysiologic effects of theophylline in young patients with recurrent symptomatic bradyarrhythmias.Am J Cardiol 1983;52:1223.
Dhingra R, Amat-Y-Leon F, Wyndham C, et al. Electrophysiologic effects of atropine on sinus node and atrium in patients with sinus nodal dysfunction.Am J Cardiol 1976;38:848.
Mertens H, Mannebach M, Trieb G, et al. Electrophysiologic and clinical findings with ipratrodium bromide.Therapie Woche 1984;50:19.
Dhingra R, Sinus node dysfunction.Pace 1983;6:1062.
Rizzon P, Di Biase M, Chiddo A, et al. Electrophysiological properties of intravenous metoprolol in man.Br Heart J 1978;40:650.
Nuttall A, Snow H. The cardiovascular effects of ICI 118, 587: A β1-adrenoceptor partial agonist.Br J Pharmac 1982;77:381.
Detry, J, Decoster P, Brasseur L. Hemodynamic effects of corwin (ICI 118,587). A new cardioselective betaadrenoceptor partial agonist.Eur Heart J 1983;4:584.
Rousseau M, Pouleur H, Vincent M. Effects of a cardioselective beta partial agonist (corwin) on left ventricular function and myocardial metabolism in patients with previous myocardial infarction.Am J Cardiol 1983;51:1267.
Bowes R, Gautam P, Graham D, et al. The electrophysiological effects of intravenous xamoterol in humans.J Electrophysiol 1987;1:266.
Narula O, Samet P, Javier R. Significance of the sinus node recovery time.Circulation 1972;45:140.
Pop T, Fleischmann D. Measurement of sinus node recovery time after atrial pacing. In: Bonke F, ed.The sinus node. Dordrecht: Martinus Nijhoff, 1978:23.
Narula O, Shantha N, Narula L, et al. Clinical and electrophysiological evaluation of sinus node function. In: Narula O, ed.Cardiac arrhythmias. Baltimore: Williams and Wilkins, 1979:176.
Capucci A, Prabetti L, Melandri G, et al. Electrophysiological properties of prenalterol.Int J Cardiol 1983;2:391.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
de Marneffe, M., Waterschoot, P., Bernard, A. et al. Electrophysiologic effects of intravenous xamoterol in patients with sinus node dysfunction. Cardiovasc Drug Ther 4, 523–527 (1990). https://doi.org/10.1007/BF01857764
Issue Date:
DOI: https://doi.org/10.1007/BF01857764