Summary
Previous studies have demonstrated that Separan AP-30, a drag-reducing polymer, significantly decreased the formation of atherosclerotic plaques in rabbits fed a highcholesterol diet. Furthermore, Separan AP-273, a polymer similar to but longer than Separan AP-30, markedly increased cardiac output in open-chest rats. Preliminary studies in our laboratory have described diuresis and natriuresis following the intravenous infusion of Separan AP-273. These studies did not determine whether this natriuresis was common to drag-reducing polymers or unique to Separan. In the present study the renal effects of two chemically dissimilar drag-reducing polymers of molecular lengths approaching ∼100 microns were compared. Sprague-Dawley rats (250–300 g) were anesthetized (Nembutalx) and a tracheostomy was performed. A baseline level of sodium and water excretion was established by the infusion of saline (0.097 ml/min, IV). Separan (0.004%), an anionic polyacrylamide; Polyox (0.4%), a poly(ethylene oxide); or mannitol (20%), an osmotic diuretic, was infused into the jugular vein at 0.0034 ml/min. Separan and Polyox both increased the excretion of sodium and water (p<0.05). At the doses tested, potassium excretion was unaltered in both groups. Separan, but not Polyox, produced a modest increase in blood pressure. Creatinine clearance was unaltered. At this infusion rate, only hypertonic concentrations of mannitol (20%) induced a similar effect. These results indicate that drag-reducing polymers may represent a novel class of potassium-sparing diuretic and natriuretic compounds. The ability of this class of polymers to decrease the formation of atherosclerotic plaques, increase blood flow, and produce a potassium-sparing natriuresis may be of practical clinical significance.
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References
Sellin RHJ, Hoyt JW, Scrivener O. The effect of dragreducing additives on fluid flows and their industrial applications.J Hydraulic Res 1982;20:29–68.
Faruqui F, Otten MD, Polimeni PI. Protection against atherogenesis with the polymer drag-reducing agent, Separan AP-30.Circulation 1987;75:627–635.
Mostardi RA, Thomas LC, Green HL, et al. Suppression of atherosclerosis in rabbits using drag reducing polymers.Biorheology 1978;15:1–14.
Polimeni PI, Ottenbreit B, Coleman P. Enhancement of aortic blood flow with a linear anionic polymer of extraordinary molecular length.J Mol Cell Cardiol 1985;17:721–724.
Coleman PB, Ottenbreit BT, Polimeni PI. Effects of a dragreducing polyelectrolyte of microscopic linear dimension (Separan AP-273) on rat hemodynamics.Circ Res 1987;61: 787–796.
Polimeni PI, Bose D, Bose R, et al. Drag-reducing polymers: A novel category of drugs potentially useful in cardiovascular disease?J Appl Cardiol 1988;3:57–66.
Smyth DD, Blandford DE, Jones DR, et al. Separan AP-273 and renal function.Can J Physiol Pharmacol 1987;65:2001–2003.
Berman NS. Drag reduction by polymers.Ann Rev Fluid Mech 1978;10:47–64.
Greene HL, Nokes RF, Thomas LC. Drag reduction phenomena in pulsed blood flow. In: Dowdell RB, ed.Flow, its Measurement and Control in Science and Industry. Pittsburgh. Instrument Society of America, 1974:1459–1464.
Castro WE. Reduction of flow-friction with polymer additions.Water Resources Institute Report 1974;24:1–56.
Stein PD, Parsons ED, Blick EF. Modification of dynamic flow properties of turbulently flowing human blood by long chain polymers.Med Res Eng 1972;11:6–10.
White WD, Hoyt JW. The effect of linear-high molecular weight polymers on the turbulent flow properties of human blood.Proc 8th Int Conf Med Biol Eng (Chicago), 1969: 11.
Polimeni PI, Ottenbreit BT. Hemodynamic effects of a poly(ethylene oxide) drag reducing polymer, Polyox WSR N-60K.J Cardiovasc Pharmacol, in press.
Polimeni PI, Al-Sadir J, Cutilletta AF. Polysaccharide for enhancement of cardiac output. US Patent 4, 154, 922, Washington, DC. 1979:1–10.
Roman RJ, Cowley AW. Characteristics of a new model for the study of pressure-natriuresis in the rat.Am J Physiol 1985;248:F190–F198.
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Symth, D.D., Polimeni, P.I. Drag-reducing polymers: A novel class of diuretic and natriuretic compounds. Cardiovasc Drug Ther 4, 297–300 (1990). https://doi.org/10.1007/BF01857648
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DOI: https://doi.org/10.1007/BF01857648