The present study examined the effects of caffeine, as typically ingested through coffee, on ambulatory systolic and diastolic blood pressure (BP), heart rate, and mood. Normotensive coffee drinkers wore a BP monitor for two 24-hr periods, consuming decaffeinated coffee. Each cup was supplemented with 125 mg caffeine or cornstarch. Systolic and diastolic BPs were elevated on the day caffeine was consumed (maximum, 3.6 and 5.6 mm Hg, respectively), most notably shortly after ingestion. Heart rate was higher overnight following caffeine consumption. Negative Affectivity was also increased by caffeine, but Positive Affectivity and tiredness were unaffected.
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American Psychological Association (1992). Ethical principles of psychologists and code of conduct.Am. Psychol. 47: 1597–1611.
Barone, J. J., and Grice, H. C. (1994). Meeting report: seventh international caffeine workshop, Santorini, Greece 13–17 June 1993.Food Chem. Tox. 32: 65–77.
Benowitz, N. L. (1990). Clinical pharmacology of caffeine.Annu. Rev. Med. 41: 277–288.
Benowitz, N. L., Hall, S. M., and Modin, G. (1989). Persistent increases in caffeine concentrations in people who stop smoking.Br. Med. J. 298: 1075–1076.
Bonham, G. S., and Leaverton, P. E. (1980).Use Habits Among Adults of Cigarettes, Coffee, Aspirin, and Sleeping Pills (Series 10, Vol. 131), Vital Health and Statistics, Washington, DC, pp. 80–1559.
Casiglia, E., Bonjiovi, S., Paleari, C. D., Petucco, S., Boni, M., Colangeli, G., Penzo, M., and Pessina, A. C. (1991). Haemodynamic effects of coffee and caffeine in normal volunteers: A placebo-controlled clinical study.J. Int. Med. 229: 501–504.
Casiglia, E., Paleari, C. D., Petucco, S., Bonjiovi, S., Colangeli, G., Baccilieri, M. S., Pavan, L., Pernice, M., and Pessina, A. C. (1992). Haemodynamic effects of coffee and purified caffeine in normal volunteers: A placebo-controlled clinical study.J. Hum. Hypertens. 6: 95–99.
Charney, D. S., Galloway, M. P., and Heninger, G. R. (1984). The effects of caffeine on plasma MHPG, subjective anxiety, autonomic symptoms, and blood pressure in healthy humans.Life Sci. 35: 135–144.
Eggertsen, R., Andreasson, A., Hedner, T., Karlberg, B. E., and Hansson, L. (1993). Effect of coffee on ambulatory blood pressure in patients with treated hypertension.J. Int. Med. 233: 351–355.
France, C., and Ditto, B. (1988). Caffeine effects on several indices of cardiovascular activity at rest and during stress.J. Behav. Med. 11: 473–482.
France, C., and Ditto, B. (1989). Cardiovascular response to occupational stress and caffeine in telemarketing employees.Psychosom. Med. 51: 145–151.
Fredholm, B. B. (1984). Cardiovascular and renal effects of methylxanthines. In Black, N., Brewer, G. J., Eijsvoogel, V. P., Grover, R., Hirschhorn, K., Kety, S. S., Udenfriend, S., and Uhr, J. W. (ser. eds.), and Spiller, G. A. (vol. ed.),Progress in Clinical and Biological Research: Vol. 158. The Methylxanthine Beverages and Foods, Alan R. Liss, New York, pp. 303–330.
Gilbert, R. M., Marshman, J. A., Schwieder, M., and Berg, R. (1976). Caffeine content of beverages as consumed.CMA J. 114: 205–208.
Gilliland, K., and Andress, D. (1981). Ad lib caffeine consumption, symptoms of caffeinism, and academic performance.Am. J. Psychiat. 138: 512–514.
Griffiths, R. R., and Woodson, P. P. (1988). Caffeine physical dependence: A review of human and laboratory animal studies.Psychopharmacology. 94: 437–451.
Griffiths, R. R., Bigelow, G. E., and Liebson, I. A. (1989). Reinforcing effects of caffeine in coffee and capsules.J. Exp. Anal. Behav. 52: 127–140.
Griffiths, R. R., Evans, S. M., Heishman, S. J., Preston, K. L., Sannerud, C. A., Wolf, B., and Woodson, P. P. (1990). Low-dose caffeine discrimination in humans.J. Pharmacol. Exp. Ther. 252: 970–978.
Grilly, D. M. (1994).Drugs and Human Behavior (2nd ed), Allyn and Bacon, Boston, pp. 193–196.
Hirsh, K. (1984). Central nervous system pharmacology of the dietary methylxanthines. In Black, N., Brewer, G. J., Eijsvoogel, V. P., Grover, R., Hirschhorn, K., Kety, S. S., Udenfriend, S., and Uhr, J. W. (ser. eds.), and Spiller, G. A. (vol. ed.),Progress in Clinical and Biological Research: Vol. 158. The Methylxanthine Beverages and Foods, Alan R. Liss, New York, pp. 235–302.
Hypertension Detection and Follow-up Program Cooperative Group (1979). Five year findings of the Hypertension Detection and Follow-up Program.JAMA 242: 2562–2571.
Jeong, D., and Dimsdale, J. E. (1990). The effects of caffeine on blood pressure in the work environment.Am. J. Hypertens. 3: 749–753.
Lane, J. D. (1983). Caffeine and cardiovascular response to stress.Psychosom. Med. 45: 447–451.
Lane, J. D. and Manus, D. C. (1989). Persistent cardiovascular effects with repeated caffeine administration.Psychosom. Med. 51: 373–380.
Lane, J. D., and Williams, R. B. (1987). Cardiovascular effects of caffeine and stress in regular coffee drinkers.Psychophysiology 24: 157–164.
Loke, W. H. (1988). Effects of caffeine on mood and memory.Physiol. Behav. 44: 367–372.
Loke, W. H. (1990). Effects of repeated caffeine administration on cognition and mood.Hum. Psychopharmacol. Clin. Exp. 5: 339–348.
Lovallo, W. R., Pincomb, G. A., Sung, B. H., Everson, S. A., Passey, R. B., and Wilson, M. F. (1991). Hypertension risk and caffeine's effect on cardiovascular activity during mental stress in young men.Health Psychol. 10: 236–243.
MacDonald, T. M., Sharpe, K., Fowler, G., Lyons, D., Freestone, S., Lovell, H. G., Webster, J., and Petrei, J. C. (1991). Caffeine restriction: Effect on mild hypertension.Br. Med. J. 303: 1235–1238.
Myers, M. G., and Reeves, R. A. (1991). The effect of caffeine on daytime ambulatory blood pressure.Am. J. Hypertens. 4: 427–431.
Parsons, W. D., and Neims, A. H. (1978). Effect of smoking on caffeine clearance.Clin. Pharmacol. Ther. 24: 40–45.
Passmore, A. P., Kondowe, G. B., and Johnston, G. D. (1987). Renal and cardiovascular effects of caffeine: A dose-response study.Clin. Sci. 72: 749–756.
Periti, M., Salvaggio, A., Quaglia, G., and DiMarzio, L. (1987). Coffee consumption and blood pressure: An Italian study.Clin. Sci. 72: 443–447.
Pickering, T. G. (1980). Sleep, circadian rhythms, and cardiovascular disease.Cardiovasc. Rev. Rep. 1: 37–46.
Pincomb, G. A., Lovallo, W. R., Passey, R. B., Whitsett, T. L., Silverstein, S. M., and Wilson, M. F. (1985). Effects of caffeine on vascular resistance, cardiac output and myocardial contractility in young men.Am. J. Cardiol. 56: 119–122.
Robertson, D., Frolich, J. C., Carr, R. K., Watson, J. T., Hollifield, J. W., Shand, D. G., and Oats, J. A. (1978). Effects of caffeine on plasma renin activity, catecholamines, and blood pressure.N. Engl. J. Med. 298: 181–186.
Robertson, D., Wade, D., Workmsn, R., Woosley, R. L., and Oats, J. A. (1981). Tolerance to the humoral and hemodynamic effects of caffeine in man.J. Clin. Invest. 67: 1111–1117.
Shi, J., Benowitz, N. L., Denaro, C. P., and Sheiner, L. B. (1993). Pharmacokinetic-pharmacodynamic modeling of caffeine: Tolerance to pressor effects.Clin. Pharmacol. Ther. 53: 6–14.
Silverman, K., and Griffiths, R. R. (1992). Low-dose caffeine discrimination and self-reported mood effects in normal volunteers.J. Exp. Behav. 57: 91–107.
Southard, D. R., Coates, T. J., Kolodner, K., Parker, F. C., Padgett, N. E., and Kennedy, H. L. (1986). Relationship between mood and blood pressure in the natural environment: An adolescent population.Health Psychol. 5: 469–480.
Spiller, G. A. (1984). Overview of the methylxanthine beverages and foods and their effect on health. In Black, N., Brewer, G. J., Eijsvoogel, V. P., Grover, R., Hirschhorn, K., Kety, S. S., Udenfriend, S., and Uhr, J. W. (ser. eds.) and Spiller, G. A. (vol. ed.),Progress in Clinical and Biological Research: Vol. 158. The Methylxanthine Beverages and Foods, Alan R. Liss, New York, pp. 1–8.
Sung, B. H., Lovallo, W. R., Pincomb, G. A., and Wilson, M. F. (1990). Effects of caffeine on blood pressure response during exercise in normotensive healthy young men.Am. J. Cardiol. 65: 909–913.
Superko, H. R., Myll, J., DiRicco, C., Williams, P. T., Bortz, W. M., and Wood, P. D. (1993). Effects of cessation of caffeinated-coffee consumption on ambulatory blood pressure and resting blood pressure in men.Am. J. Cardiol. 73: 780–784.
Van Dusseldorp, M., and Katan, M. B. (1990). Headache caused by caffeine withdrawal among moderate coffee drinkers switched from ordinary to decaffeinated coffee: A 12-week double-blind trial.Br. Med. J. 300: 1558–1559.
Van Dusseldorp, M., Smits, P., Thein, T., and Katan, M. B. (1989). Effects of decaffeinated versus regular coffe on blood pressure.Hypertension 14: 563–569.
Van Dusseldorp, M., Smits, P., Lenders, J. W. M., Thein, T., and Katan, M. B. (1991). Boiled coffee and blood pressure: A 14-week controlled trial.Hypertension 18: 607–613.
Watson, D. (1988). The vicissitudes of mood measurement: Effect of varying descriptors, time frames, and response formats on measures of positive and negative affect.J. Person. Soc. Psychol. 55: 128–141.
Watson, D., and Tellegen, A. (1985). Toward a consensual structure of mood.Psychol. Bull. 98: 219–235.
Watson, D., Clark, L. A., and Tellegen, A. (1988). Development and validation of brief measures of positive and negative affect: The PANAS Scales.J. Person. Soc. Psychol. 54: 1063–1070.
White, B. C., Lincoln, C. A., Pearce, N. W., Reeb, R., and Vaida, C. (1980). Anxiety and muscle tension as consequences of caffeine withdrawal.Science 209: 1547–1548.
Zwyghuizen-Doorenbos, A., Roehrs, T. A., Lipschutz, L., Timms, V., and Roth, T. (1990) Effects of caffeine on alertness.Psychopharmacology 100: 36–39.
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Green, P.J., Suls, J. The effects of caffeine on ambulatory blood pressure, heart rate, and mood in coffee drinkers. J Behav Med 19, 111–128 (1996). https://doi.org/10.1007/BF01857602
- ambulatory blood pressure